Evidence map›Paper›PMID 37890552›Full record

ReviewJournal of molecular and cellular cardiology2023

Clustering properties of the cardiac ryanodine receptor in health and heart failure.

Helen M M Waddell, Valeria Mereacre, Francisco J Alvarado, Michelle L Munro

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Structural Integrity of RyR2 Clusters Controls Cardiac Calcium Leak.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024
    Article
  10. Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  11. Article
  12. Article
  13. Effects of acteoside fromFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Helen M M WaddellDepartment of Physiology and HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Valeria MereacreDepartment of Physiology and HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Francisco J AlvaradoDepartment of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Michelle L MunroDepartment of Physiology and HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand. Electronic address: michelle.munro@otago.ac.nz.
University of Otago · NZUniversity of Wisconsin–Madison · US

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4M
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R01 HL167195NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

The cardiac ryanodine receptor (RyR2) is an intracellular Ca

Indexed as

Heart FailureRyanodine Receptor Calcium Release ChannelCalciumCalcium SignalingHumansMyocytes, CardiacSarcoplasmic ReticulumCalciumRyanodine Receptor Calcium Release ChannelClustersHeart failureNanoscale remodellingRyanodine receptor

Identifiers

PMID37890552
PMCPMC10717225
OpenAlexW4387996755

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.