Evidence map›Paper›PMID 37890857›Full record

ArticleJournal of veterinary internal medicine

Giardiasis and diarrhea in dogs: Does the microbiome matter?

Sharon Kuzi, Soha Zgairy, Barbara A Byrne, Jan Suchodolski, Sondra C Turjeman, So Young Park, Itamar Aroch, Mike Hong, Omry Koren, Eran Lavy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sharon KuziHebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment Hebrew University of Jerusalem, Rehovot, Israel.ORCID https://orcid.org/0000-0001-7130-1706
Soha ZgairyAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Barbara A ByrneDepartment of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, California, USA.
Jan SuchodolskiGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-2176-6932
Sondra C TurjemanAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.ORCID https://orcid.org/0000-0002-5224-1215
So Young ParkGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.
Itamar ArochHebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment Hebrew University of Jerusalem, Rehovot, Israel.
Mike HongGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.
Omry KorenAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Eran LavyHebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment Hebrew University of Jerusalem, Rehovot, Israel.
Bar-Ilan University · ILHebrew University of Jerusalem · ILTexas College · USUniversity of California, Davis · US

Funding

Center for Companion Animal Health, University of California, DavisFaculty Allotment Funds, School of Veterinary Medicine, University of California, DavisKoret School of Veterinary Medicine, Hebrew University of Jerusalem #2018-69-KG
6 · The paper itself

Abstract

backgroundGiardia duodenalis (Gd) causes intestinal parasitosis. The involvement of the intestinal microbiome in determining the infection's clinical phenotype is unknown.

objectiveInvestigate the fecal microbiome features in dogs with giardiasis. ANIMALS AND

methodsCross-sectional study, including fecal samples of kenneled dogs with Gd diagnosed by fecal Giardia antigen dot ELISA. The fecal microbial compositional characteristics and dysbiosis index (DI) were compared between diarrheic and nondiarrheic dogs.

resultsFecal samples of 38 Gd-infected dogs (diarrheic, 21; nondiarrheic, 17) were included. No differences were found in Faith's phylogenic diversity and beta diversity (weighted UniFrac distances) and in specific taxa abundances at the phylum, genus, and species levels, as well as in alpha and beta diversities between diarrheic and nondiarrheic dogs, and also when divided by sex or age. Among diarrheic dogs, alpha diversity was higher in males than in females (pairwise Kruskal-Wallis, q = 0.01). Among males, fecal abundances of the genus Clostridium (W = 19) and Clostridium spiroforme species (W = 33) were higher in diarrheic compared to nondiarrheic dogs. In diarrheic dog fecal samples, Proteobacteria were more prevalent (W = 1), whereas Verrucomicrobia were less prevalent in dogs <1 year of age than in older dogs. The fecal sample DI of 19 diarrheic and 19 nondiarrheic dogs was similar (median, -0.2; range, -4.3 to 4.5 and median, -1.0; range, -4.3 to 5.8, respectively).

conclusionsThe fecal microbial composition of symptomatic and asymptomatic dogs with giardiasis is similar. Based on fecal DI, giardiasis is not characterized by prominent dysbiosis. Other host and parasite characteristics might determine the severity of giardiasis in dogs.

Indexed as

Dog DiseasesGiardiasisMicrobiotaAnimalsCross-Sectional StudiesDiarrheaDogsDysbiosisFecesFemaleMalecanineClostridiumdysbiosis indexGiardia duodenalisproteobacteriaVerrucomicrobia

Identifiers

PMID37890857
PMCPMC10800182
OpenAlexW4387968162

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.