Evidence map›Paper›PMID 37891561›Full record

ArticleCardiovascular diabetology2023

C-reactive protein during pregnancy and in the early postpartum predicts adverse metabolic health outcomes at 1 year postpartum in women with gestational diabetes.

Dan Yedu Quansah, Antje Horsch, Leah Gilbert, Marc Y Donath, Jardena J Puder, MySweetheart research group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Dan Yedu QuansahObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Rue du Bugnon 21, CH-1011, Lausanne, Switzerland. dan.quansah@chuv.ch.
Antje HorschInstitute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, Lausanne, Switzerland.
Leah GilbertObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Rue du Bugnon 21, CH-1011, Lausanne, Switzerland.
Marc Y DonathEndocrinology, Diabetes and Metabolism, University Hospital Basel, and Department of Biomedicine, University of Basel, Basel, Switzerland.
Jardena J PuderObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Rue du Bugnon 21, CH-1011, Lausanne, Switzerland.
MySweetheart research group
University of Lausanne · CHInstitute for Work and Health · CHUniversity Hospital of Basel · CH

Funding

Swiss National Science Foundation SNF32003B_176119
6 · The paper itself

Abstract

backgroundWomen with gestational diabetes mellitus (GDM) have higher insulin resistance and/or reduced secretion, an increased risk of future diabetes and cardiovascular disease, which may be due to a pathological activation of the innate immune system. C-reactive protein (CRP) is induced by inflammatory cytokines and reflects innate immune activity. We investigated the prospective associations between CRP during the perinatal period with adverse metabolic outcomes at 1 year postpartum in women with previous GDM.

methodsWe analyzed data from the MySweetheart trial that included 211 women with GDM at 28-32 weeks gestational age (GA). CRP was measured during  pregnancy at 28-32 weeks GA, at 6-8 weeks and at 1 year postpartum. Metabolic outcomes at 1 year postpartum included weight, total and central body fat, measures of insulin resistance and secretion and presence of the metabolic syndrome (MetS). A 75 g oral glucose tolerance test was performed to measure glucose and insulin values every 30 min over 2 h to calculate indices of insulin resistance (MATSUDA, HOMA-IR) and of absolute (AUC

resultsCRP during pregnancy and at 6-8 weeks postpartum predicted increased weight, body fat and visceral adipose tissue (VAT), insulin resistance (higher HOMA-IR, lower MATSUDA), absolute insulin secretion (HOMA-B, AUC

Indexed as

Diabetes, GestationalInsulin ResistanceMetabolic SyndromeBlood GlucoseC-Reactive ProteinFemaleHumansInsulinOutcome Assessment, Health CarePostpartum PeriodPregnancyBlood GlucoseC-Reactive ProteinInsulinBody fatC-reactive proteinGestational diabetesInsulin resistanceInsulin secretionMetabolic outcomesPerinatal periodPostpartum

Identifiers

PMID37891561
PMCPMC10612338
OpenAlexW4387996138

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.