Evidence map›Paper›PMID 37895049›Full record

ArticleInternational journal of molecular sciences2023

A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.

Chying-Chyuan Chan, Te-Hsin Yen, Hao-Chen Tseng, Brang Mai, Pin-Kuan Ho, Jian-Liang Chou, Gwo-Jang Wu, Yu-Chuan Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chying-Chyuan ChanGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.
Te-Hsin YenDepartment of Obstetrics and Gynecology, Taipei City Hospital-Renai Branch, Taipei 103212, Taiwan.
Hao-Chen TsengSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.
Brang MaiSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.
Pin-Kuan HoSchool of Dentistry, National Defense Medical Center, Taipei 114201, Taiwan.
Jian-Liang ChouGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.
Gwo-Jang WuGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.ORCID 0000-0001-5360-8018
Yu-Chuan HuangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.
National Defense Medical Center · TWTaipei City Hospital · TWTri-Service General Hospital · TW

Funding

Ministry National Defense Medical Affairs Bureau MAB-109-032 & MND-MAB-D-112153Taipei City Hospital TPCH-108-45Tri-Service General Hospital TSGH-A-111012
6 · The paper itself

Abstract

Advanced reproductive technologies are utilized to identify the genetic mutations that lead to spermatogenic impairment, and allow informed genetic counseling to patients to prevent the transmission of genetic defects to offspring. The purpose of this study was to identify potential single nucleotide polymorphisms (SNPs) associated with male infertility. Genetic variants that may cause infertility are identified by combining the targeted next-generation sequencing (NGS) panel and whole exome sequencing (WES). The validation step of Sanger sequencing adds confidence to the identified variants. Our analysis revealed five distinct affected genes covering seven SNPs based on the targeted NGS panel and WES data:

Indexed as

AzoospermiaInfertility, MaleCystic Fibrosis Transmembrane Conductance RegulatorHumansMaleMultigene FamilyMutationCystic Fibrosis Transmembrane Conductance Regulatorazoospermiamale infertilitymicrotubule-associated genesnext-generation sequencingoligozoospermiasingle nucleotide polymorphism

Identifiers

PMID37895049
PMCPMC10607339
OpenAlexW4387780915

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.