ArticleInternational journal of molecular sciences2023
A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP).
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Redefining Fascia: A Mechanobiological Hub and Stem Cell Reservoir in Regeneration-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Systematic Review on Working Mechanisms of Signaling Pathways in Fibrosis During Shockwave Therapy.International journal of molecular sciences · 2024Pooled it
- Deciphering the function and mechanism of extracorporeal shock wave therapy in knee osteoarthritis (Review).International journal of molecular medicine · 2026Review
- Common Fascial Abnormalities in Five Thumb Pain Conditions: A Fifteen-Point Ultrasound-Guided Fascia Hydrorelease Clinical Protocol.Journal of functional morphology and kinesiology · 2026Article
- The Fascial Capacitor Model: A Biophysical Hypothesis for the Origin of the Local Twitch Response Within Stacking Fascia.International journal of molecular sciences · 2026Article
- Fascia as a Functional System in Health and Disease: From Fundamental Biology to Assessment and Targeted Interventions.International journal of molecular sciences · 2026Review
- Local Twitches During Ultrasound-Guided Fascial Hydrorelease Occur Within Stacking Fascia: A Retrospective Analysis of a Large Video Archive.Medical sciences (Basel, Switzerland) · 2026Article
- A Conceptual Fascial Memory Reset Hypothesis: Mechanobiological Insights into Stacking Fascia as an Ultrasound-Visible Structural Phenotype and the Potential Role of Fascial Hydrorelease.International journal of molecular sciences · 2026Article
- The perspective of manual therapy as a fascia-directed biomechanical intervention in myofascial pain syndrome.Frontiers in medicine · 2026Article
- Understanding Fascial Tissue on the Molecular Level-How Its Unique Properties Enable Adaptation or Dysfunction.International journal of molecular sciences · 2025Review
- Stochastic Nature of Fascia: From Layered Pedagogical Artifact to Morphogenetic Reality in Clinical Anatomy.Life (Basel, Switzerland) · 2025Article
- Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research.Regenerative therapy · 2025Review
- Angiotensin II Activates Yes-Associated Protein (YAP) in Fibroblast Promoting Deep Fascia Remodeling.International journal of molecular sciences · 2025Article
- An Emerging Perspective on the Role of Fascia in Complex Regional Pain Syndrome: A Narrative Review.International journal of molecular sciences · 2025Review
- Exploring the Revolutionary Impact of YAP Pathways on Physical and Rehabilitation Medicine.Biomolecules · 2025Review
- Effect of high glucose on the gene expression profiling in cardiac fibroblasts from rats at different ages.PeerJ · 2025Article
- Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Ultrasound Imaging in Football Players with Previous Multiple Ankle Sprains: Keeping a Close Eye on Superior Ankle Retinaculum.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated that fascial fibroblasts are susceptible to mechanical stimuli, leading to the remodeling of the extracellular matrix (ECM). Moreover, the extensive literature on Yes-associated protein (YAP) has shown its role in cell mechanics, linking cell properties, such as shape, adhesion, and size, to the expression of specific genes. The aim of this study was to investigate the presence of YAP in deep fascia and its activation after a mechanical stimulus was induced via a focal extracorporeal shockwave (fESW) treatment. Thoracolumbar fascia (TLF) samples were collected from eight patients (age: 30-70 years; four males and four females) who had undergone spine elective surgical procedures at the Orthopedic Clinic of University of Padova. YAP was measured in both tissue and TLF-derived fibroblasts through immunoblotting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.