Evidence map›Paper›PMID 37895311›Full record

ArticleGenes2023

Multi-Trait Exome-Wide Association Study of Back Pain-Related Phenotypes.

Irina V Zorkoltseva, Elizaveta E Elgaeva, Nadezhda M Belonogova, Anatoliy V Kirichenko, Gulnara R Svishcheva, Maxim B Freidin, Frances M K Williams, Pradeep Suri, Yakov A Tsepilov, Tatiana I Axenovich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Irina V ZorkoltsevaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Elizaveta E ElgaevaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Nadezhda M BelonogovaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Anatoliy V KirichenkoInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-9972-9517
Gulnara R SvishchevaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0001-9478-267X
Maxim B FreidinDepartment of Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-1439-6259
Frances M K WilliamsDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Pradeep SuriSeattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Yakov A TsepilovInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-4931-6052
Tatiana I AxenovichInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-4318-4458
Institute of Cytology and Genetics · RUKing's College London · GBNovosibirsk State University · RUQueen Mary University of London · GBUniversity of Washington · US

Funding

UW Core Center for Clinical Research of Musculoskeletal ConditionsP30AR072572 · NIAMS · UNIVERSITY OF WASHINGTON · PI JEFFREY G JARVIK, Pradeep Suri · 2017 to 2026
$8.3M
NIAMS NIH HHS P30 AR072572
6 · The paper itself

Abstract

Back pain (BP) is a major contributor to disability worldwide, with heritability estimated at 40-60%. However, less than half of the heritability is explained by common genetic variants identified by genome-wide association studies. More powerful methods and rare and ultra-rare variant analysis may offer additional insight. This study utilized exome sequencing data from the UK Biobank to perform a multi-trait gene-based association analysis of three BP-related phenotypes: chronic back pain, dorsalgia, and intervertebral disc disorder. We identified the

Indexed as

ExomeGenome-Wide Association StudyBack PainGenetic Predisposition to DiseaseHumansPhenotypechronic back paindorsalgiaFSCN3intervertebral disc disorderlinear combination of traitsloss-of-function (LoF) variantrare and ultra-rare genetic variantsshared heritabilitySLC13A1

Identifiers

PMID37895311
PMCPMC10606006
OpenAlexW4387782306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.