Evidence map›Paper›PMID 37895849›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Galangal-Cinnamon Spice Mixture Blocks the Coronavirus Infection Pathway through Inhibition of SARS-CoV-2 M

Doaa G El-Hosari, Wesam M Hussein, Marwa O Elgendy, Sara O Elgendy, Ahmed R N Ibrahim, Alzhraa M Fahmy, Afnan Hassan, Fatma Alzahraa Mokhtar, Modather F Hussein, Mohamed E A Abdelrahim and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Doaa G El-HosariPharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.ORCID 0000-0002-2679-8976
Wesam M HusseinPharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Marwa O ElgendyDepartment of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt.ORCID 0000-0002-5466-0552
Sara O ElgendyClinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt.
Ahmed R N IbrahimDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Alzhraa M FahmyTropical Medicine and Infectious Diseases Department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt.ORCID 0000-0001-7243-3006
Afnan HassanBiomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Cairo 12578, Egypt.ORCID 0000-0001-8434-4449
Fatma Alzahraa MokhtarDepartment of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida 44813, Egypt.ORCID 0000-0002-6909-7440
Modather F HusseinChemistry Department, Collage of Science, Jouf University, P.O. Box 2014, Sakaka 72388, Saudi Arabia.ORCID 0000-0003-3664-2745
Mohamed E A AbdelrahimClinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62521, Egypt.ORCID 0000-0003-0227-8404
Eman G HaggagPharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.ORCID 0000-0003-4424-160X
Beni-Suef University · EGHelwan University · EGAl-Azhar University · EGKing Khalid University · SAZewail City of Science and Technology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products such as domestic herbal drugs which are easily accessible and cost-effective can be used as a complementary treatment in mild and moderate COVID-19 cases. This study aimed to detect and describe the efficiency of phenolics detected in the galangal-cinnamon mixture in the inhibition of SARS-CoV-2's different protein targets. The potential antiviral effect of galangal-cinnamon aqueous extract (GCAE) against Low Pathogenic HCoV-229E was assessed using cytopathic effect inhibition assay and the crystal violet method. Low Pathogenic HCoV-229E was used as it is safer for in vitro laboratory experimentation and due to the conformation and the binding pockets similarity between HCoV-229E and SARS-CoV-2 M

Indexed as

antiviral assaygalangal–cinnamon aqueous extractphenolic compoundsquantum-chemical methodsSARS-CoV-2 MPro

Identifiers

PMID37895849
PMCPMC10610207
OpenAlexW4387136081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.