Evidence map›Paper›PMID 37895863›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1

Nahed Nasser Eid El-Sayed, Taghreed M Al-Otaibi, Assem Barakat, Zainab M Almarhoon, Mohd Zaheen Hassan, Maha I Al-Zaben, Najeh Krayem, Vijay H Masand, Abir Ben Bacha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Nahed Nasser Eid El-SayedEgyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St., Giza 35521, Egypt.
Taghreed M Al-OtaibiDepartment of Chemistry, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Assem BarakatDepartment of Chemistry, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-7885-3201
Zainab M AlmarhoonDepartment of Chemistry, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-8196-2612
Mohd Zaheen HassanDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0002-8235-5379
Maha I Al-ZabenDepartment of Chemistry, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Najeh KrayemLaboratoire de Biochimie et de Génie Enzymatique des Lipases, ENIS, Université de Sfax, Route de Soukra 3038, Sfax BP 1173, Tunisia.
Vijay H MasandDepartment of Chemistry, Vidya Bharati College, Camp, Amravati, Maharashtra 444602, India.
Abir Ben BachaBiochemistry Department, College of Sciences, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.ORCID 0000-0001-6372-7483
King Saud University · SAKing Khalid University · SANational Organization for Drug Control and Research · EGUniversity of Sfax · TN

Funding

Deanship of Scientific Research at King Saud University Research Group No. RGP-070
6 · The paper itself

Abstract

Oxidative stress, COX-2, LDHA and hyperglycemia are interlinked contributing pathways in the etiology, progression and metastasis of colon cancer. Additionally, dysregulated apoptosis in cells with genetic alternations leads to their progression in malignant transformation. Therefore, quinazolinones

Indexed as

ADMETapoptosiscolorectal cancerCOX-2inflammationLDHAoxidative stresspost prandial hyperglycemiaquinazolinoneWarburg effect

Identifiers

PMID37895863
PMCPMC10610505
OpenAlexW4387234995

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.