Evidence map›Paper›PMID 37896179›Full record

ArticlePharmaceutics2023

Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway.

Hoda A Salem, Karema Abu-Elfotuh, Sharifa Alzahrani, Nermin I Rizk, Howaida S Ali, Nehal Elsherbiny, Alhanouf Aljohani, Ahmed M E Hamdan, Panneerselvam Chellasamy, Nada S Abdou and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Hoda A SalemDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-6089-6062
Karema Abu-ElfotuhDepartment of Clinical Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Sharifa AlzahraniDepartment of Pharmacology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.
Nermin I RizkMedical Physiology Department, Faculty of Medicine, Menoufia University, Menouf 32952, Egypt.
Howaida S AliDepartment of Pharmacology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.
Nehal ElsherbinyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Alhanouf AljohaniFaculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Ahmed M E HamdanDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-4930-792X
Panneerselvam ChellasamyDepartment of Biology, Faculty of Science, Tabuk University, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-3994-8141
Nada S AbdouFaculty of Medicine, Misr University for Science and Technology (MUST), Giza 11556, Egypt.
Ayah M H GowifelPharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo 11571, Egypt.ORCID 0000-0003-1738-7101
Alshaymaa DarwishBiochemistry Department, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
Osama Mohamed IbrahimClinical Pharmacy Department, Faculty of Pharmacy, University of Tanta, Tanta 31527, Egypt.
Zakaria Y Abd ElmageedDepartment of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana at Monroe, Monroe, LA 71203, USA.ORCID 0000-0003-4031-0348
University of Tabuk · SAAl-Azhar University · EGMansoura University · EGMenoufia University · EGMisr University for Science and Technology · EGModern University for Information and Technology · EGSohag University · EGTanta University · EGUniversity of Louisiana at Monroe · US

Funding

University of Tabuk 0050-1443-S
6 · The paper itself

Abstract

Parkinson's disease (PD) is a gradual deterioration of dopaminergic neurons, leading to motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention as a potential influencing factor in the progress of neurodegenerative illnesses. We aimed to investigate the intricate relationship between SI and PD progression, both independently and in the presence of manganese chloride (MnCl

Indexed as

AMPK/SIRT-1HMGB1/RAGE/TLR4/NF-ᴋB/NLRP3Parkinson’s diseasePI3K/AKT/GSK-3β/CREBPUNsocial isolation

Identifiers

PMID37896179
PMCPMC10610313
OpenAlexW4387334630

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.