Evidence map›Paper›PMID 37897616›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Impact of simulated reduced injected dose on the assessment of amyloid PET scans.

Peter Young, Fiona Heeman, Jan Axelsson, Lyduine E Collij, Anne Hitzel, Amirhossein Sanaat, Aida Niñerola-Baizan, Andrés Perissinotti, Mark Lubberink, Giovanni B Frisoni and 9 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Article
  5. Ultra-fast [EJNMMI physics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Peter Young *Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-4818-4270
Fiona Heeman *Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-7769-8329
Jan AxelssonDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-3731-3612
Lyduine E CollijDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6263-1762
Anne HitzelDepartment of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
Amirhossein SanaatDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-8437-2060
Aida Niñerola-BaizanNuclear Medicine Department, Hospital Clínic Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7306-5775
Andrés PerissinottiNuclear Medicine Department, Hospital Clínic Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4190-2425
Mark LubberinkNuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8324-7399
Giovanni B FrisoniLaboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-6419-1753
Habib ZaidiDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-7559-5297
Frederik BarkhofDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3543-3706
Gill FarrarGE Healthcare, Amersham, UK.ORCID http://orcid.org/0000-0002-0726-723X
Suzanne BakerHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, USA.ORCID http://orcid.org/0000-0003-0209-3127
Juan Domingo GispertBarcelona βeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6155-0642
Valentina GaribottoDivision of Nuclear Medicine and Molecular Imaging, University Hospitals of Geneva; NIMTLab; Center for Biomedical Imaging (CIBM), University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-2422-698X
Anna RieckmannInstitute for Psychology, Universität Der Bundeswehr München, Neubiberg, Germany.ORCID http://orcid.org/0000-0002-5389-1578
Michael SchöllWallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. michael.scholl@neuro.gu.se.ORCID http://orcid.org/0000-0001-7800-1781
AMYPAD consortium

Funding

Innovative Medicines Initiative 115372Innovative Medicines Initiative 115952
6 · The paper itself

Abstract

purposeTo investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [

methodsCognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [

resultsAt 5% injected dose, change in SUVR was 3.72% and 3.12%, with absolute change in Centiloid 3.35CL and 4.62CL, for [

conclusionThis proof-of-concept study showed that for both [

Indexed as

Alzheimer DiseaseAniline CompoundsStilbenesAmyloidAmyloid beta-PeptidesBenzothiazolesBrainHumansPositron-Emission Tomography4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbeneAmyloidAmyloid beta-PeptidesAniline CompoundsBenzothiazolesflutemetamolStilbenesAlzheimer’s diseaseAmyloidDose reductionNeuroimagingPET

Identifiers

PMID37897616
PMCPMC10796642

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.