Evidence map›Paper›PMID 37897839›Full record

ArticleJournal of psychiatric research2023

Pre-treatment frontal beta events are associated with executive dysfunction improvement after repetitive transcranial magnetic stimulation for depression: A preliminary report.

Brian C Kavanaugh, Andrew M Fukuda, Zachary T Gemelli, Ryan Thorpe, Eric Tirrell, Megan Vigne, Stephanie R Jones, Linda L Carpenter

Open access · greenAbstract read
In one paragraph

Article in Journal of psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Transdiagnostic Attentional Deficits Are Associated with Depressive and Externalizing Symptoms in Children and Adolescents with Neuropsychiatric Disorders.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brian C KavanaughE.P. Bradley Hospital, United States; Brown University, Department of Psychiatry & Human Behavior, United States. Electronic address: Brian_Kavanaugh@Brown.edu.
Andrew M FukudaBrown University, Department of Psychiatry & Human Behavior, United States; Butler Hospital, United States.
Zachary T GemelliBrown University, Department of Psychiatry & Human Behavior, United States; Rhode Island Hospital, United States.
Ryan ThorpeBrown University, Department of Neuroscience, United States.
Eric TirrellBrown University, Department of Psychiatry & Human Behavior, United States; Butler Hospital, United States.
Megan VigneBrown University, Department of Psychiatry & Human Behavior, United States; Butler Hospital, United States.
Stephanie R JonesBrown University, Department of Neuroscience, United States; Providence Veteran's Association Medical Center, Center for Neurorestoration and Neurotechnology, United States.
Linda L CarpenterBrown University, Department of Psychiatry & Human Behavior, United States; Butler Hospital, United States.
John Brown University · US

Funding

Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI VAN 'T WOUT-FRANK, MASCHA · 2019 to 2023
$11.3M
NIGMS NIH HHS P20 GM130452
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an established clinical treatment for major depressive disorder (MDD) that has also been found to improve aspects of executive functioning. The objective of this study was to examine whether oscillatory burst-like events within the beta band (15-29 Hz) prior to treatment could predict subsequent change in self-reported executive dysfunction (EDF) across a clinical course of rTMS for MDD. Twenty-eight adults (64% female) with MDD completed the self-report Frontal Systems Behavior Scale (FrSBe) and provided eyes-closed resting-state electroencephalography (EEG) before and after a clinical course of rTMS therapy for primary MDD. The rate, power, duration, and frequency span of transient EEG measured oscillatory beta events were calculated. Events within delta/theta and alpha bands were examined to assess for beta specificity. After controlling for improvement in primary depressive symptoms, a lower rate of beta events at F3, Fz, F4, and Cz prior to rTMS treatment was associated with a larger improvement in EDF after rTMS treatment. In addition, a decrease in beta event rate at Fz pre-to-post treatment was associated with a larger improvement in EDF after treatment. Results were largely specific to the beta band. In this study, the rate of frontrocentral beta events prior to treatment significantly predicted the likelihood of subsequent improvement in EDF symptoms following a clinical course of rTMS for MDD. These preliminary findings suggest the potential utility of EEG measured beta events and rTMS for targeting EDF across an array of neuropsychiatric disorders.

Indexed as

Major Depressive DisorderTranscranial Magnetic StimulationAdultDepressionDisease ProgressionFemaleHumansMalePrefrontal CortexTreatment OutcomeBeta bandBiomarkersDepressionExecutive functionsOscillatory eventsTranscranial magnetic stimulation

Identifiers

PMID37897839
PMCPMC11542745
OpenAlexW4387694002

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.