SynthesisJournal of Parkinson's disease2023
Is There an Association Between Parkinson's Disease and Periodontitis? A Systematic Review and Meta-Analysis.
Synthesis in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Association between oral dysbiosis and Parkinson's disease: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Dental Caries Experience in Older Adults With Parkinson's Disease: A Systematic Review and Meta-Analysis.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryPooled it
- Mapping oral-systemic health relationships: a data-driven analysis of co-occurrence patterns in biomedical literature.JAMIA open · 2026Article
- Association between periodontal and geriatric health: a cross-sectional study.Clinical oral investigations · 2026Article
- Oral health and oral microbiota composition in patients with Parkinson's disease: a case‒control study.Journal of oral microbiology · 2026Article
- Impact of Oral Immunity on Neuroinflammation and Neurodegenerative Diseases.Advances in experimental medicine and biology · 2026Review
- Periodontitis and Parkinson's disease: a narrative review of associations, proposed mechanisms, and clinical considerations.Frontiers in oral health · 2026Review
- Crossroads of well-being: oral health, neurology, neuronutrition and healthy aging.Open medicine (Warsaw, Poland) · 2026Review
- The link between oral health and neurodegeneration: a review of periodontitis in Alzheimer's and Parkinson's disease and dementia.Inflammopharmacology · 2025Review
- Association of Chronic Periodontitis with Migraine in a Korean Adult Population: A Nationwide Nested Case-Control Study.Healthcare (Basel, Switzerland) · 2025Article
- Long-Term Safety and Efficacy of Repeated Cycles of RimabotulinumtoxinB in the Treatment of Chronic Sialorrhea: Results of the OPTIMYST Trial.Neurology and therapy · 2025Article
- Evaluating dental health in patients with different severity of Parkinson's disease: a cross-sectional study.BMC oral health · 2025Article
- Periodontitis: Grade Modifiers Revisited.Oral diseases · 2025Review
- Kufor-Rakeb Syndrome in a Guatemalan Patient With anCase reports in genetics · 2025Article
- Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study.Journal of inflammation research · 2025Article
- Periodontitis: A Plausible Modifiable Risk Factor for Neurodegenerative Diseases? A Comprehensive Review.International journal of molecular sciences · 2024Review
- Investigating the Connection between Chronic Periodontitis and Parkinson's Disease: Findings from a Korean National Cohort Study.Biomedicines · 2024Article
- Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?Brain sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple observational studies have yielded controversial results regarding the association between Parkinson's disease (PD) and periodontitis.
objectiveThis systematic review and meta-analysis was conducted to ascertain their bidirectional relationship.
methodsA literature search for relevant studies was performed in PubMed, EMBASE, the Cochrane Library, and Web of Science databases from inception to December 19, 2022. Effect sizes (ES) with 95% confidence intervals were pooled under the random-effects model. Then, leave-one-out sensitivity analysis and contour-enhanced funnel plot were applied to assess the stability of the results.
resultsA total of 34 studies and 24 studies were included for systematic review and quantitative meta-analysis, respectively. Pooled ES indicated that periodontitis was not significantly associated with PD risk (HR = 1.13, 95% CI 0.88-1.45, n = 3; OR = 1.94, 95% CI 0.55-6.90, n = 7), while the Mendelian randomization study revealed no association between PD and periodontitis risk (coefficient [B] = -0.0001, standard error = 0.0001, p = 0.19). Furthermore, PD patients exhibited higher levels of periodontal pocket depth (SMD = 1.10, 95% CI 0.53-1.67), clinical attachment level (SMD = 1.40, 95% CI 0.55-2.26), plaque index (SMD = 0.81, 95% CI 0.22-1.39), and Oral Health Impact Profile-14 score (SMD = 0.91, 95% CI 0.33-1.49) compared to healthy controls.
conclusionsOur meta-analysis identified no bidirectional association between PD risk and periodontitis risk, though the prevalence of periodontitis and poorer oral status was higher in PD patients.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.