ArticleJournal of intellectual disability research : JIDR2024
Obesity, diabetes and their metabolic correlates in middle-aged adults with Down syndrome.
Article in Journal of intellectual disability research : JIDR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 9 citations in OpenAlex.
- Are Bioimpedance Parameters Altered in Adults With Down Syndrome? A Cross-Sectional Study.Journal of intellectual disability research : JIDR · 2026Article
- Outcomes of a multidisciplinary lifestyle intervention in adults with Down syndrome : A retrospective observational study.Wiener klinische Wochenschrift · 2026Article
- Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome.Obesity (Silver Spring, Md.) · 2026Article
- What Is Known About Persons with Intellectual Disabilities and Cardiovascular Risk Factors-A Scoping Review.Epidemiologia (Basel, Switzerland) · 2026Review
- Gut Microbiota Differences in Down Syndrome Are Most Pronounced in Childhood and Diminish With Age.International journal of microbiology · 2026Article
- Examination of metabolic syndrome in Down syndrome and association with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Leptin levels are associated with body mass index and Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Adults with Down syndrome and obstructive sleep apnea treated with hypoglossal nerve stimulation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Anthropometric and metabolic assessment in adults with Down syndrome: the need for novel indices and tailored criteria.Turkish journal of medical sciences · 2025Article
- Metabolic dysfunction-associated liver disease and biliary lithiasis in children with Down Syndrome: a retrospective study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Article
- Body composition parameters and sarcopenia in adults with Down syndrome: a case-control study.Aging clinical and experimental research · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity in adults without Down syndrome is associated with an adverse metabolic profile including high prevalence of pre-diabetes and diabetes, high levels of insulin, non-high-density lipoprotein (HDL) cholesterol, leptin and high-sensitivity C-reactive protein (hsCRP) and low levels of HDL and adiponectin. We examined whether obesity in middle-aged adults with Down syndrome is also related to an adverse metabolic profile.
methodsThis cross-sectional study included 143 adults with Down syndrome, with a mean age of 55.7 ± 5.7 years and 52.5% women. Body mass index (BMI) was classified as underweight (BMI < 18.5 kg/m
resultsThe majority of the sample had an overweight (46.9%) or obesity (27.3%) status. However, there was a relatively low prevalence of pre-diabetes (9.8%) and diabetes (6.9%). Overweight and obesity status were not associated with lower HDL and adiponectin and higher insulin, non-HDL cholesterol and hsCRP as expected in adults without Down syndrome. However, overweight and obesity were strongly associated with higher leptin (P < 0.001).
conclusionsThe only metabolic correlate of obesity in middle-aged adults with Down syndrome was high leptin levels. Our findings are limited by non-fasting laboratory tests but suggest that middle-aged adults with Down syndrome do not have the adverse metabolic profile related to obesity found in adults without Down syndrome.
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Registered trials
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