Evidence map›Paper›PMID 37904233›Full record

ArticleCell communication and signaling : CCS2023

Indacaterol inhibits collective cell migration and IGDQ-mediated single cell migration in metastatic breast cancer MDA-MB-231 cells.

Sophie Ayama-Canden, Rodolfo Tondo, Martha Liliana Pineros Leyton, Noëlle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Aude Sauvage, Tijani Tabarrant, Stéphane Lucas and 2 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Sophie Ayama-CandenURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Rodolfo TondoCardiff University, Park Place, Main Building, Wales, CF10 3AT, UK.
Martha Liliana Pineros LeytonURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Noëlle NinaneURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Catherine DemazyURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Marc DieuMaSUN, Mass Spectrometry Facility, University of Namur, 61, Rue de Bruxelles, 5000, Namur, Belgium.
Antoine FattaccioliURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Aude SauvageURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Tijani TabarrantLARN - NARILIS, University of Namur, Rue de Bruxelles 61, Namur, 5000, Belgium.
Stéphane LucasLARN - NARILIS, University of Namur, Rue de Bruxelles 61, Namur, 5000, Belgium.
Davide BonifaziCardiff University, Park Place, Main Building, Wales, CF10 3AT, UK.
Carine MichielsURBC - NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium. carine.michiels@unamur.be.
University of Namur · BECardiff University · GBUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is the main cause of deaths related to breast cancer. This is particular the case for triple negative breast cancer. No targeted therapies are reported as efficient until now. The extracellular matrix, in particular the fibronectin type I motif IGDQ, plays a major role in regulating cell migration prior metastasis formation. This motif interacts with specific integrins inducing their activation and the migratory signal transduction.Here, we characterized the migratory phenotype of MDA-MB-231 cells, using functionalized IGDQ-exposing surfaces, and compared it to integrin A5 and integrin B3 knock-down cells. A multiomic analysis was developed that highlighted the splicing factor SRSF6 as a putative master regulator of cell migration and of integrin intracellular trafficking. Indacaterol-induced inhibition of SRSF6 provoked: i) the inhibition of collective and IGDQ-mediated cell migration and ii) ITGA5 sequestration into endosomes and lysosomes. Upon further studies, indacaterol may be a potential therapy to prevent cell migration and reduce metastasis formation in breast cancer. Video Abstract.

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsCell AdhesionCell Line, TumorCell MovementFemaleHumansIndansIntegrinsMDA-MB-231 CellsPhosphoproteinsQuinolonesSerine-Arginine Splicing FactorsindacaterolIndansIntegrinsPhosphoproteinsQuinolonesSerine-Arginine Splicing FactorsSRSF6 protein, humanBreast cancerCell migrationFibronectin type IIGDQ motogenic motifIndacaterolIntegrin alpha 5Integrin beta 3MetastasisMotogenicSRFS6

Identifiers

PMID37904233
PMCPMC10614342
OpenAlexW4388023425

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.