Evidence map›Paper›PMID 37906637›Full record

ArticleACS infectious diseases2023

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery.

Catherine N Russell, Jennifer L Carter, Juliet M Borgia, Jacob Bush, Félix Calderón, Raquel Gabarró, Stuart J Conway, Jeremy C Mottram, Anthony J Wilkinson, Nathaniel G Jones

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Identification of novel bromodomain inhibitors ofAntimicrobial agents and chemotherapy · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Catherine N RussellYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, York YO10 5DD, U.K.
Jennifer L CarterDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0009-0007-0542-2033
Juliet M BorgiaYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, York YO10 5DD, U.K.
Jacob BushGSK, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.ORCID 0000-0001-7165-0092
Félix CalderónGSK Global Health, Tres Cantos, 28760 Madrid, Spain.
Raquel GabarróGSK Global Health, Tres Cantos, 28760 Madrid, Spain.
Stuart J ConwayDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0002-5148-117X
Jeremy C MottramYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5NG, U.K.ORCID 0000-0001-5574-3766
Anthony J WilkinsonYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, York YO10 5DD, U.K.
Nathaniel G JonesYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5NG, U.K.ORCID 0000-0001-7328-4487
University of York · GBMansfield University · USAge UK · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M011151/1Medical Research Council MR/P027989/1Wellcome TrustWellcome Trust 204829
6 · The paper itself

Abstract

Leishmaniases are a collection of neglected tropical diseases caused by kinetoplastid parasites in the genus

Indexed as

Antiprotozoal AgentsFactor VBromodomain Containing ProteinsDrug DiscoveryHistonesHumansProtein DomainsTranscription FactorsAntiprotozoal AgentsBRD9 protein, humanBromodomain Containing ProteinsFactor VHistonesTranscription Factorsbromodomaindrug discoveryepigeneticsLeishmaniastructural biology

Identifiers

PMID37906637
PMCPMC10644352
OpenAlexW4388040825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.