Evidence map›Paper›PMID 37907501›Full record

ArticleScientific reports2023

Significant up-regulation of lncRNAs in neuromyelitis optica spectrum disorder.

Mohammad Taheri, Ahmad Sadeghi, Alireza Gharebaghi, Masoud Ghiasian, Solat Eslami, Sheyda Khalilian, Arezou Sayad, Soudeh Ghafouri-Fard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Mohammad TaheriInstitute of Human Genetics, Jena University Hospital, Jena, Germany.
Ahmad SadeghiDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza GharebaghiNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Masoud GhiasianDepartment of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
Solat EslamiDietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Sheyda KhalilianDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arezou SayadDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ar.sayad@yahoo.com.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.
Shahid Beheshti University of Medical Sciences · IRHamedan University of Medical Sciences · IRAlborz University of Medical SciencesJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating defect. Long non-coding RNAs (lncRNAs) might influence the pathobiology and progression of NMOSD. The current study assessed expression level of NEAT1, PANDAR, MEG3 and TUG1 lncRNAs in the peripheral blood of NMOSD patients compared with healthy individuals. All mentioned lncRNAs were shown to be over-expressed in total NMOSD cases, male NMOSD cases and female NMOSD cases compared with the matching control subgroups. MEG3 had the most robust over-expression in patients subgroups compared with normal subjects. There was no noteworthy difference in the expression of any of lncRNAs between female and male patients. MEG3 had an ideal performance in the differentiation of NMOSD cases from healthy persons (Sensitivity and specificity values = 100%). Other lncRNAs could also efficiently separate NMOSD cases from control subjects (AUC values = 0.97, 0.89 and 0.88 for PANDAR, NEAT1 and TUG1, respectively). Cumulatively, NEAT1, PANDAR, MEG3 and TUG1 lncRNAs can be considered as appropriate disease markers for NMOSD.

Indexed as

Neuromyelitis OpticaRNA, Long NoncodingFemaleHealth StatusHumansMaleUp-RegulationRNA, Long Noncoding

Identifiers

PMID37907501
PMCPMC10618193
OpenAlexW4388073389

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.