Evidence map›Paper›PMID 37907765›Full record

ArticleTissue engineering and regenerative medicine2024

Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering.

Reetta Sartoneva, Kaarlo Paakinaho, Markus Hannula, Kirsi Kuismanen, Heini Huhtala, Jari Hyttinen, Susanna Miettinen

Open access · hybridAbstract read
In one paragraph

Article in Tissue engineering and regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Reetta SartonevaFaculty of Medicine and Health Technology (MET), Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland. reetta.sartoneva@tuni.fi.ORCID 0000-0001-5492-571X
Kaarlo PaakinahoFaculty of Medicine and Health Technology (MET), Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Markus HannulaFaculty of Medicine and Health Technology (MET), Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Kirsi KuismanenTays Research Services, Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Heini HuhtalaFaculty of Social Sciences, University of Tampere, Tampere, Finland.
Jari HyttinenFaculty of Medicine and Health Technology (MET), Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Susanna MiettinenFaculty of Medicine and Health Technology (MET), Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Tampere University · FITampere University Hospital · FI

Funding

Academy of Finland 312413Academy of Finland 339405Competitive Research Funding of the Pirkanmaa Hospital District 9AB069Suomen Lääketieteen Säätiö 3856
6 · The paper itself

Abstract

backgroundThe reconstructive surgery of vaginal defects is highly demanding and susceptible to complications, especially in larger defects requiring nonvaginal tissue grafts. Thus, tissue engineering-based solutions could provide a potential approach to the reconstruction of vaginal defects.

methodsHere, we evaluated a novel porous ascorbic acid 2-phosphate (A2P)-releasing supercritical carbon dioxide foamed poly-L-lactide-co-ε-caprolactone (scPLCL

resultsBoth ECs and SCs maintained their viability on the scPLCL

conclusionThis is the first study evaluating the effect of A2P on vaginal tissue engineering, and the results are highly encouraging, indicating that scPLCL

Indexed as

Tissue EngineeringTissue ScaffoldsAscorbic AcidCaproatesCollagenFemaleHumansLactonesPolyestersPorosityStromal Cellsascorbate-2-phosphateAscorbic AcidCaproatescaprolactoneCollagenLactonesPolyesterspoly(lactide)Ascorbic acid 2-phosphatePoly-L-lactide-co-ε-caprolactonePorous scaffoldVaginal epithelial cellVaginal stromal cellVaginal tissue engineering

Identifiers

PMID37907765
PMCPMC10764701
OpenAlexW4388067632

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.