ArticleRadiology. Cardiothoracic imaging2023
Predictive Value of Deep Learning-derived CT Pectoralis Muscle and Adipose Measurements for Incident Heart Failure: Multi-Ethnic Study of Atherosclerosis.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005487 (Multi-Ethnic Study of Atherosclerosis), which is not on this map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-Ethnic Study of Atherosclerosis (MESA)
Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development and validation of a nomogram for predicting pulmonary embolism recurrence using muscle and fat parameters.Scientific reports · 2026Article
- Interpretable hybrid deep learning features of pectoralis on low-dose chest CT for detecting type 2 diabetes.Frontiers in endocrinology · 2026Article
- Cardiac MRI Pectoralis Muscle Thickness as a Measure of Sarcopenia: Prognostic Significance, Interreader Agreement, and Physiologic Correlation.Radiology. Cardiothoracic imaging · 2024Article
- Correlation of Sarcopenia with Coronary Artery Disease Severity and Pericoronary Adipose Tissue Attenuation: A Coronary CT Study.Tomography (Ann Arbor, Mich.) · 2024Observational
- Post-mortem skeletal survey (PMSS) versus post-mortem computed tomography (PMCT) for the detection of corner metaphyseal lesions (CML) in children.European radiology · 2024Article
- CT-derived pectoralis composition and incident pneumonia hospitalization using fully automated deep-learning algorithm: multi-ethnic study of atherosclerosis.European radiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Quincy Hathaway *From the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0001-8226-2319
Hamza Ahmed Ibad *From the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0003-1557-9484
David A BluemkeFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0002-8323-8086
Farhad PishgarFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0003-0703-8442
Arta KasaieanFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).
Joshua G KleinFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0002-7810-6767
Rebecca CogswellFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).
Matthew AllisonFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0003-0777-8272
Matthew J BudoffFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0002-9616-1946
R Graham BarrFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).
Wendy PostFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0002-8655-5204
Miriam A BredellaFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0001-5482-0440
João A C LimaFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0001-8756-6995
Shadpour DemehriFrom the School of Medicine, West Virginia University, Morgantown, WV (Q.H.); Russell H. Morgan Department of Radiology and Radiological Sciences (H.A.I., F.P., A.K., J.G.K., S.D.) and Division of Cardiology, Department of Medicine (W.P., J.A.C.L.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Medicine, University of Minnesota, Minneapolis, Minn (R.C.); Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif (M.A.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.J.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.A.B.).ORCID https://orcid.org/0000-0001-5991-5924
Johns Hopkins University · US
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MTO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN J · 2020 to 2025
$3.4MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NIAMS NIH HHS R01 AR079620
Abstract
Purpose: To develop a deep learning algorithm capable of extracting pectoralis muscle and adipose measurements and to longitudinally investigate associations between these measurements and incident heart failure (HF) in participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and Methods: MESA is a prospective study of subclinical cardiovascular disease characteristics and risk factors for progression to clinically overt disease approved by institutional review boards of six participating centers (ClinicalTrials.gov identifier: NCT00005487). All participants with adequate imaging and clinical data from the fifth examination of MESA were included in this study. Hence, in this secondary analysis, manual segmentations of 600 chest CT examinations (between the years 2010 and 2012) were used to train and validate a convolutional neural network, which subsequently extracted pectoralis muscle and adipose (intermuscular adipose tissue (IMAT), perimuscular adipose tissue (PAT), extramyocellular lipids and subcutaneous adipose tissue) area measurements from 3031 CT examinations using individualized thresholds for adipose segmentation. Next, 1781 participants without baseline HF were longitudinally investigated for associations between baseline pectoralis muscle and adipose measurements and incident HF using crude and adjusted Cox proportional hazards models. The full models were adjusted for variables in categories of demographic (age, race, sex, income), clinical/laboratory (including physical activity, BMI, and smoking), CT (coronary artery calcium score), and cardiac MRI (left ventricular ejection fraction and mass (% of predicted)) data. Results: In 1781 participants (median age, 68 (IQR,61, 75) years; 907 [51%] females), 41 incident HF events occurred over a median 6.5-year follow-up. IMAT predicted incident HF in unadjusted (hazard ratio [HR]:1.14; 95% CI: 1.03-1.26) and fully adjusted (HR:1.16, 95% CI: 1.03-1.31) models. PAT also predicted incident HF in crude (HR:1.19; 95% CI: 1.06-1.35) and fully adjusted (HR:1.25; 95% CI: 1.07-1.46) models. Conclusion: The study demonstrates that fast and reliable deep learning-derived pectoralis muscle and adipose measurements are obtainable from conventional chest CT, which may be predictive of incident HF.©RSNA, 2023.
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NCT00005487ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.