Evidence map›Paper›PMID 37908862›Full record

ArticleHemaSphere2023

Momelotinib in Myelofibrosis Patients With Thrombocytopenia: Post Hoc Analysis From Three Randomized Phase 3 Trials.

Jean-Jacques Kiladjian, Alessandro M Vannucchi, Aaron T Gerds, Vikas Gupta, Srdan Verstovsek, Miklos Egyed, Uwe Platzbecker, Jiří Mayer, Sebastian Grosicki, Árpád Illés and 10 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Emerging Therapeutic Approaches for Anemia in Myelofibrosis.Current hematologic malignancy reports · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 10 countries.

Jean-Jacques KiladjianUniversité de Paris, AP-HP, Hôpital Saint-Louis, Centre d'Investigations Cliniques, INSERM, Paris, France.ORCID https://orcid.org/0000-0002-8121-438X
Alessandro M VannucchiDepartment of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, Florence, Italy.
Aaron T GerdsCleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Vikas GuptaPrincess Margaret Cancer Center, University of Toronto, ON, Canada.
Srdan VerstovsekThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Miklos EgyedTeaching Hospital Mór Kaposi, Kaposvár, Hungary.
Uwe PlatzbeckerClinic of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, Germany.
Jiří MayerDepartment of Internal Medicine, Haematology and Oncology, University Hospital Brno, Czech Republic.
Sebastian GrosickiDepartment of Hematology and Cancer Prevention, Faculty of Health Sciences in Bytom, Silesian Medical University, Katowice, Poland.
Árpád IllésDepartment of Hematology, Faculty of Medicine, University of Debrecen, Hungary.
Tomasz WoźnyDepartment of Hematology, Szpital MSWiA w Poznaniu, Poznan, Poland.
Stephen T OhDepartment of Medicine and Department of Pathology and Immunology, Division of Hematology, Washington University School of Medicine, St. Louis, MO, USA.
Donal McLornanGuy's and St Thomas' NHS Foundation Trust and University College London Hospitals, London, United Kingdom.
Ilya KirgnerThe Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel.
Sung-Soo YoonDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Claire N HarrisonGuy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Barbara KlenckeSierra Oncology, a GSK company, San Mateo, CA, USA.
Mei HuangSierra Oncology, a GSK company, San Mateo, CA, USA.
Jun KawashimaSierra Oncology, a GSK company, San Mateo, CA, USA.
Ruben MesaAtrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Guy's and St Thomas' NHS Foundation Trust · GBAtrium Health Wake Forest Baptist · USCentral European Institute of Technology · CZCleveland Clinic · USInserm · FRMedical University of Silesia · PLSeoul National University · KRSomogy Megyei Kaposi Mór Oktató Kórház · HUTel Aviv University · ILThe University of Texas MD Anderson Cancer Center · USUniversity of Debrecen · HUUniversity of Florence · ITUniversity of Toronto · CAWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral activin A receptor type I, Janus kinase 1 (JAK1), and JAK2 inhibitor momelotinib demonstrated symptom, spleen, and anemia benefits in intermediate- and high-risk myelofibrosis (MF). Post hoc analyses herein evaluated the efficacy and safety of momelotinib in patients with MF and thrombocytopenia (platelet counts <100 × 10

Identifiers

PMID37908862
PMCPMC10615557
OpenAlexW4387969051

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.