Evidence map›Paper›PMID 37909412›Full record

ArticleJournal of cellular physiology2023

Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single-cell resolution.

Lisbeth Berrueta, Dennis Muñoz-Vergara, Daniel Martin, Rebecca Thompson, Brian E Sansbury, Matthew Spite, Gary J Badger, Helene M Langevin

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06949007 (Yoga for Persistent Post-Surgical Pain), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06949007 narecruitingnot on this mapstarted 2026, after this paper: background citation

Yoga for Persistent Post-Surgical Pain (PPSP)

TypeinterventionalSponsorBrigham and Women's HospitalRan2026 to 2029Enrolled50ConditionsPersistent Post-surgical PainArmsYoga, Chronic Pain Health Education
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. The Science of Tai Chi andJournal of integrative and complementary medicine · 2025
    Review
  4. Ethanol extract fromBiotechnologia · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lisbeth BerruetaConnective Tissue Section, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland, USA.ORCID 0000-0002-5674-6448
Dennis Muñoz-VergaraDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Daniel MartinConnective Tissue Section, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland, USA.
Rebecca ThompsonConnective Tissue Section, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland, USA.
Brian E SansburyDivision of Cardiovascular Medicine, University of Louisville, Louisville, Kentucky, USA.
Matthew SpiteDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Gary J BadgerDepartment of Medical Biostatistics, University of Vermont, Burlington, Vermont, USA.
Helene M LangevinConnective Tissue Section, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland, USA.
National Institute of Dental and Craniofacial Research · USBrigham and Women's Hospital · USUniversity of Louisville · USUniversity of Vermont Medical Center · US

Funding

Exploring the effect of stretching in the resolution of Connective tissue inflammation ZIADE000756 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI BERRUETA, LISBETH · 2020 to 2025
$1.6M
Effect of Stretching on Inflammatory ResolutionR01AT009267 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI LANGEVIN, HELENE M · 2016 to 2018
$1.4M
Intramural NIH HHS ZIA DE000756NCCIH NIH HHS R01 AT009267NIDCR NIH HHS
6 · The paper itself

Abstract

Understanding the factors that influence the biological response to inflammation is crucial, due to its involvement in physiological and pathological processes, including tissue repair/healing, cancer, infections, and autoimmune diseases. We have previously demonstrated that in vivo stretching can reduce inflammation and increase local pro-resolving lipid mediators in rats, suggesting a direct mechanical effect on inflammation resolution. Here we aimed to explore further the effects of stretching at the cellular/molecular level in a mouse subcutaneous carrageenan-inflammation model. Stretching for 10 min twice a day reduced inflammation, increased the production of pro-resolving mediator pathway intermediate 17-HDHA at 48 h postcarrageenan injection, and decreased both pro-resolving and pro-inflammatory mediators (e.g., PGE

Indexed as

InflammationNeutrophilsAnimalsCarrageenanDinoprostoneInflammation MediatorsMacrophagesMiceMice, Inbred C57BLSingle-Cell AnalysisTranscriptomeCarrageenanDinoprostoneInflammation Mediatorscarrageenan inflammationlipidomicsresolutionsingle-cell RNA sequencingstretching

Identifiers

PMID37909412
PMCPMC10773986
OpenAlexW4388129643

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.