Evidence map›Paper›PMID 37910328›Full record

Observational studyObesity surgery2023

Weight-loss Independent Clinical and Metabolic Biomarkers Associated with Type 2 Diabetes Remission Post-bariatric/metabolic Surgery.

Kusuma Chaiyasoot, Naomi S Sakai, Roxanna Zakeri, Janine Makaronidis, Luís Crisóstomo, Marco G Alves, Wei Gan, Chloe Firman, Friedrich C Jassil, Margaret A Hall-Craggs and 2 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Recent progress of remission in type 2 diabetes.Therapeutic advances in endocrinology and metabolism · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Kusuma ChaiyasootDepartment of Medicine, Centre for Obesity Research, University College London, London, UK.
Naomi S SakaiUCL Centre for Medical Imaging, London, UK.
Roxanna ZakeriDepartment of Medicine, Centre for Obesity Research, University College London, London, UK.
Janine MakaronidisDepartment of Medicine, Centre for Obesity Research, University College London, London, UK.
Luís CrisóstomoDepartment of Immunophysiology and Pharmacology, ICBAS - School of Medicine and Biomedical Sciences, UMIB - Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.
Marco G AlvesDepartment of Immunophysiology and Pharmacology, ICBAS - School of Medicine and Biomedical Sciences, UMIB - Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.
Wei GanGenetics Department, Novo Nordisk Research Centre Oxford, Innovation Building, Old Road Campus, Headington, OX37LQ, UK.
Chloe FirmanDepartment of Medicine, Centre for Obesity Research, University College London, London, UK.
Friedrich C JassilDepartment of Medicine, Centre for Obesity Research, University College London, London, UK.
Margaret A Hall-CraggsUCL Centre for Medical Imaging, London, UK.
Stuart A TaylorUCL Centre for Medical Imaging, London, UK.
Rachel L BatterhamDepartment of Medicine, Centre for Obesity Research, University College London, London, UK. r.batterham@ucl.ac.uk.ORCID 0000-0002-5477-8585
National Institute for Health Research · GBUniversity College London · GBNovo Nordisk (United Kingdom) · GBSiriraj Hospital · THUniversidade do Porto · PTUniversity of Turku · FI

Funding

National Institute for Health and Care Research RP-2015-06-005Rosetrees Trust CM710
6 · The paper itself

Abstract

purposeRemission of type 2 diabetes (T2D) can be achieved by many, but not all, people following bariatric/metabolic surgery. The mechanisms underlying T2D remission remain incompletely understood. This observational study aimed to identify novel weight-loss independent clinical, metabolic and genetic factors that associate with T2D remission using comprehensive phenotyping. MATERIALS AND

methodsTen patients without T2D remission (non-remitters) were matched to 10 patients with T2D remission (remitters) for age, sex, type of surgery, body weight, BMI, post-operative weight loss, duration from surgery and duration of T2D. Detailed body composition assessed using magnetic resonance imaging, gut hormones, serum metabolomics, insulin sensitivity, and genetic risk scores for T2D and anthropometric traits were assessed.

resultsRemitters had significantly greater β-cell function and circulating acyl ghrelin levels, but lower visceral adipose tissue (VAT): subcutaneous adipose tissue (SAT) ratio than non-remitters. Branched-chain amino acids (BCAAs) and VLDL particle size were the most discriminant metabolites between groups. A significant positive correlation between, VAT area, VAT:SAT ratio and circulating levels of BCAAs was observed, whereas a significant negative correlation between BCAAs and β-cell function was revealed.

conclusionWe highlight a potentially novel relationship between VAT and BCAAs, which may play a role in glucoregulatory control. Improvement in β-cell function, and the role ghrelin plays in its recovery, is likely another key factor influencing T2D remission post-surgery. These findings suggest that adjunctive approaches that target VAT loss and restoration of BCAA metabolism might achieve higher rates of long-term T2D remission post-surgery.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Obesity, MorbidBiomarkersGhrelinHumansTreatment OutcomeWeight LossBiomarkersGhrelinMetabolic surgeryObesityRemissionType 2 diabetes

Identifiers

PMID37910328
PMCPMC10687127
OpenAlexW4388111077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.