ArticleNature2023
Epigenetic regulation during cancer transitions across 11 tumour types.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
28.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
139 citing papers in PubMed, 182 citations in OpenAlex.
- Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization.Bioactive materials · 2027Article
- PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026Review
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- Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cells.Research square · 2026Article
- Robust and generalizable CNV detection for single-cell sequencing assays.Nucleic acids research · 2026Article
- Single cell spatial transcriptomics track the evolutionary hierarchy and microenvironment remodeling during breast carcinoma invasion.Nature communications · 2026Article
- Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma.Genes & genomics · 2026Article
- Evaluating agentic AI for biological discovery in autonomous and copilot settings.bioRxiv : the preprint server for biology · 2026Article
- Tumour-Derived Extracellular Vesicles Reprogramme Tumour-Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma.Journal of extracellular vesicles · 2026Article
- GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.Cell reports · 2026Article
- EPHB2 drives EMT-linked vasculogenic mimicry and cervical cancer progression via an ERK-ETV4 transcriptional program.Journal of translational medicine · 2026Article
- Inferring tumor absolute copy number and clonal substructure from single-cell chromatin accessibility.Briefings in bioinformatics · 2026Article
- Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states.Science China. Life sciences · 2026Article
- Association between Diagnostic History and Cancer Incidence within 5 Years: A Real-world Observational Analysis.Cancer research communications · 2026Observational
- CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species.Nature methods · 2026Article
- Epigenetic insights into minimal residual disease detection in cancer.Genes & diseases · 2026Article
- Epigenetic and ncRNA Regulation of CBX2 in Liver Hepatocellular Carcinoma: A Comprehensive Multi-Omics Analysis for Understanding Biological Significance.Medicina (Kaunas, Lithuania) · 2026Article
- cfDECOR: a novel approach for estimating cell type contributions to cfDNA based on chromatin accessibility patterns.Scientific reports · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 5 institutions in 2 countries.
Nadezhda V Terekhanova *Department of Medicine, Washington University in St Louis, St Louis, MO, USA.
Alla Karpova *Department of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0467-0215
Wen-Wei Liang *Department of Medicine, Washington University in St Louis, St Louis, MO, USA.
Alexander StrzalkowskiDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Siqi ChenDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Yize LiDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-1074-281X
Austin N Southard-SmithDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0022-6897
Michael D IglesiaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-0841-2144
Michael C WendlDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Reyka G JayasingheDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-2368-4890
Jingxian LiuDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Yizhe SongDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-8760-6432
Song CaoDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Andrew HoustonDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Xiuting LiuDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Matthew A WyczalkowskiDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-4197-551X
Rita Jui-Hsien LuDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-7434-6544
Wagma CaravanDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-4082-6723
Andrew ShinkleDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Nataly Naser Al DeenDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
John M HerndonDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-8378-9654
Jacqueline MuddDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.
Cong MaDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Hirak SarkarDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Kazuhito SatoDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0589-7454
Omar M IbrahimDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-9903-6657
Chia-Kuei MoDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Sara E ChasnoffDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.
Eduard Porta-PardoJosep Carreras Leukaemia Research Institute, Barcelona, Spain.
Jason M HeldDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-8024-2736
Russell PachynskiDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Julie K SchwarzDepartment of Radiation Oncology, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-2407-7531
William E GillandersDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-0465-3071
Albert H KimSiteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-1751-8493
Ravi VijDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
John F DiPersioDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-0429-3133
Sidharth V PuramDepartment of Otolaryngology-Head & Neck Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3543-889X
Milan G ChhedaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-8282-9098
Katherine C FuhDepartment of Obstetrics and Gynecology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7693-2694
David G DeNardoDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Ryan C FieldsDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA. rcfields@wustl.edu.ORCID 0000-0001-6176-8943
Feng ChenDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA. fchen@wustl.edu.ORCID 0000-0002-2307-7954
Benjamin J RaphaelDepartment of Computer Science, Princeton University, Princeton, NJ, USA. braphael@princeton.edu.ORCID 0000-0003-1274-048X
Li DingDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.ORCID 0000-0003-1517-2975
James S. McDonnell Foundation · USWashington University in St. Louis · USPrinceton University · USBarcelona Supercomputing Center · ESUniversity of California, San Francisco · US
Funding
Washington University SPORE in Pancreatic CancerP50CA272213 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo, WILLIAM G HAWKINS · 2023 to 2026
$10.7MWASHINGTON UNIVERSITY HUMAN TUMOR ATLAS RESEARCH CENTERU2CCA233303 · NCI · WASHINGTON UNIVERSITY · PI DING, LI · 2018 to 2023
$9.7MINSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4MWU-SN-TMC Data Analysis CoreU54AG075934 · NIA · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2021 to 2026
$8.0MWashington University (WU) ROBIN Center: MicroEnvironment and Tumor Effects Of Radiotherapy (METEOR)U54CA274318 · NCI · WASHINGTON UNIVERSITY · PI Geoffrey D Hugo · 2023 to 2026
$7.7MComprehensive and Robust Tools for Analysis of Tumor Heterogeneity and EvolutionU24CA248453 · NCI · PRINCETON UNIVERSITY · PI Benjamin Raphael · 2020 to 2026
$4.7MProteogenomic Data Analysis for Cancer Systems Biology and Clinical TranslationU24CA210972 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DING, LI, FENYO, DAVID · 2016 to 2020
$3.3MImpact of cancer predisposition on oncogenic process, microenvironment, and treatmentR01CA260112 · NCI · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2022 to 2026
$2.4MPathogenic Variant Discovery Across a Broad Spectrum of Human DiseasesR01HG009711 · NHGRI · WASHINGTON UNIVERSITY · PI CHEN, FENG, DING, LI · 2017 to 2020
$2.2MNCI NIH HHS P50 CA272213NCI NIH HHS R01 CA260112NCI NIH HHS U24 CA210972NCI NIH HHS U24 CA248453NCI NIH HHS U2C CA233303NCI NIH HHS U54 CA274318NHGRI NIH HHS R01 HG009711NHGRI NIH HHS T32 HG000045NIA NIH HHS U54 AG075934
Abstract
Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis
Indexed as
Epigenesis, GeneticGene Expression Regulation, NeoplasticNeoplasmsATP-Binding Cassette, Sub-Family C ProteinsCell HypoxiaCell NucleusChromatinEnhancer Elements, GeneticEpithelial-Mesenchymal TransitionEstrogensFibroblast Growth FactorsGATA6 Transcription FactorGene Expression ProfilingGTPase-Activating ProteinsHomeodomain ProteinsHumansASAP2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsChromatinEN1 protein, humanEstrogensFGF19 protein, humanFibroblast Growth FactorsGATA6 protein, humanGATA6 Transcription FactorGTPase-Activating ProteinsHomeodomain Proteinsmultidrug resistance-associated protein 1proto-oncogene protein Pbx3Proto-Oncogene ProteinsTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53Vascular Endothelial Growth Factor AVEGFA protein, human
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.