Evidence map›Paper›PMID 37915324›Full record

ReviewFrontiers in medicine2023

Philadelphia chromosome-negative myeloproliferative chronic neoplasms: is clonal hematopoiesis the main determinant of autoimmune and cardio-vascular manifestations?

Giovanni Fulvio, Chiara Baldini, Marta Mosca, Antonello di Paolo, Guido Bocci, Giuseppe Alberto Palumbo, Emma Cacciola, Paola Migliorini, Rossella Cacciola, Sara Galimberti

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Giovanni Fulvio *Department of Clinical and Experimental Medicine, Rheumatology, University of Pisa, Pisa, Italy.
Chiara Baldini *Department of Clinical and Experimental Medicine, Rheumatology, University of Pisa, Pisa, Italy.
Marta MoscaDepartment of Clinical and Experimental Medicine, Rheumatology, University of Pisa, Pisa, Italy.
Antonello di PaoloDepartment of Clinical and Experimental Medicine, Clinical Pharmacology, University of Pisa, Pisa, Italy.
Guido BocciDepartment of Clinical and Experimental Medicine, Clinical Pharmacology, University of Pisa, Pisa, Italy.
Giuseppe Alberto PalumboDepartment of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Hematology, University of Catania, Catania, Italy.
Emma CacciolaDepartment of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Hemostasis, University of Catania, Catania, Italy.
Paola MiglioriniDepartment of Clinical and Experimental Medicine, Clinical Immunology, University of Pisa, Pisa, Italy.
Rossella CacciolaDepartment of Clinical and Experimental Medicine, Hemostasis, University of Catania, Catania, Italy.
Sara GalimbertiDepartment of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy.
University of Pisa · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, we reviewed the possible mechanisms linking the clonal hematopoiesis of indeterminate potential (CHIP) to chronic myeloproliferative neoplasms (MPNs), autoimmune diseases (ADs), and cardiovascular diseases (CADs). CHIP is characterized by the presence of clonal mutations with an allelic frequency >2% in the peripheral blood without dysplasia, overt hematological neoplasms, or abnormalities in blood cell count. The prevalence may reach 20% of elderly healthy individuals and is considered a risk factor for myelodysplastic neoplasms and acute leukemia. In MPNs, CHIP is often associated with mutations such as

Indexed as

autoimmune diseasecardiovascular diseaseCHIPDNMT3AJAK2myeloproliferative neoplasmsROCK2TET2

Identifiers

PMID37915324
PMCPMC10616863
OpenAlexW4387703583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.