Evidence map›Paper›PMID 37915463›Full record

ArticleTransplantation direct2023

Sodium Hydrosulfide Treatment During Porcine Kidney Ex Vivo Perfusion and Transplantation.

Thomas Agius, Julien Songeon, Arnaud Lyon, Justine Longchamp, Raphael Ruttimann, Florent Allagnat, Sébastien Déglise, Jean-Marc Corpataux, Déla Golshayan, Léo Buhler and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Thomas AgiusDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Julien SongeonDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Arnaud LyonDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Justine LongchampDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Raphael RuttimannVisceral and Transplant Surgery, Department of Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
Florent AllagnatDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Sébastien DégliseDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Jean-Marc CorpatauxDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Déla GolshayanDepartment of Medicine, Transplantation Centre, Lausanne University Hospital, Lausanne, Switzerland.
Léo BuhlerSection of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland.
Raphael MeierDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Heidi YehDepartment of Surgery, Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
James F MarkmannDepartment of Surgery, Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Korkut UygunDepartment of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Christian TosoVisceral and Transplant Surgery, Department of Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
Antoine KlauserDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Francois LazeyrasDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Alban LongchampDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
University of Lausanne · CHHarvard University · USCentre d'Imagerie BioMedicale · CHMassachusetts General Hospital · USUniversity Hospital of Geneva · CHUniversity of Geneva · CHUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In rodents, hydrogen sulfide (H Methods: Adult porcine kidneys retrieved immediately or after 60 min of warm ischemia (WI) were exposed to 100 µM sodium hydrosulfide (NaHS) (1) during the hypothermic ex vivo perfusion only, (2) during WI only, and (3) during both WI and ex vivo perfusion. Kidney perfusion was evaluated with dynamic contrast-enhanced MRI. MRI spectroscopy was further employed to assess energy metabolites including ATP. Renal biopsies were collected at various time points for histopathological analysis. Results: Perfusion for 4 h pig kidneys with Belzer MPS UW + NaHS resulted in similar renal perfusion and ATP levels than perfusion with UW alone. Similarly, no difference was observed when NaHS was administered in the renal artery before ischemia. After autotransplantation, no improvement in histologic lesions or cortical/medullary kidney perfusion was observed upon H Conclusions: In conclusion, treatment of porcine kidney grafts using NaHS did not result in a significant reduction of ischemia-reperfusion injury or improvement of kidney metabolism. Future studies will need to define the benefits of H

Identifiers

PMID37915463
PMCPMC10617874
OpenAlexW4388021196

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.