Evidence map›Paper›PMID 37915496›Full record

ArticleToxicology research2023

DNA methylome profiling in occupational radon exposure miners using an Illumina Infinium Methylation EPIC BeadChip.

Pinhua Zhang, Yunyun Wu, Chunnan Piao, Yanchao Song, Yanfang Zhao, Yumin Lyu, Quanfu Sun, Jianxiang Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pinhua ZhangKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.ORCID https://orcid.org/0000-0002-6848-4254
Yunyun WuKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.
Chunnan PiaoKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.ORCID https://orcid.org/0000-0002-4349-9564
Yanchao SongKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.
Yanfang ZhaoThe Third People's Hospital of Henan Province, Henan Hospital for Occupational Diseases, 3 Kangfu Middle Street, Erqi District, Zhengzhou 450052, China.
Yumin LyuThe Third People's Hospital of Henan Province, Henan Hospital for Occupational Diseases, 3 Kangfu Middle Street, Erqi District, Zhengzhou 450052, China.
Quanfu SunKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.
Jianxiang LiuKey Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 2 Xinkang Street, Deshengmenwai, Xicheng District, Beijing 100088, China.
Chinese Center For Disease Control and Prevention · CNThird Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A causal relationship between occupational radon exposure in underground miners and lung cancer risk has been demonstrated through large cohort epidemiological studies. However, the mechanisms by which radon exposure causes adverse effects on lung tissue remain unclear. Epigenetic alterations such as DNA methylation may provide new insights into interactions at molecular levels induced by prolonged radon exposure. Methods: We used the Illumina Infinium Human Methylation 850 K BeadChip to detect and compare genome-wide DNA methylation profiles in peripheral blood samples from underground miners (n = 14) and aboveground workers (n = 9). Results: The average concentration of radon in underground workplaces was significantly higher than that of aboveground places (1,198 Bq·m Conclusion: In summary, the DNA methylation pattern of the underground miners exposed to radon was distinct from that of the aboveground workers. Such abnormalities in the genomic DNA methylation profile associated with prolonged radon exposure are worth studying in terms of neuro- and immune-system regulation, as well as cell adhesion ability in the future.

Indexed as

bioinformaticsDNA methylationEPIC BeadChipoccupational exposureradonunderground miners

Identifiers

PMID37915496
PMCPMC10615836
OpenAlexW4387015201

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.