Evidence map›Paper›PMID 37915607›Full record

ArticleiScience2023

Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function.

Xiaowen Liang, Sung Yun Jung, Lon Wolf Fong, Gamze Bildik, Joshua P Gray, Weiqun Mao, Shuxing Zhang, Steven W Millward, Alemayehu A Gorfe, Yong Zhou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiaowen LiangDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Sung Yun JungDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Lon Wolf FongDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Gamze BildikDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Joshua P GrayDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Weiqun MaoDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Shuxing ZhangDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Steven W MillwardDepartment of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Alemayehu A GorfeDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.
Yong ZhouDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.
Zhen LuDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Robert C BastDepartment of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · USBaylor College of Medicine · US

Funding

The University of Texas MD Anderson Cancer Center SPORE in Ovarian CancerP50CA281701 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ROBERT C BAST, ANIL K SOOD · 2023 to 2026
$11.5M
DIRAS3 disrupts K-RAS clustering and signaling, enhancing autophagy and response to autophagy inhibitionR01CA266187 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C, LU, ZHEN · 2022 to 2025
$2.9M
NCI NIH HHS P50 CA281701NCI NIH HHS R01 CA266187
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CancerProtein physicsStructural biology

Identifiers

PMID37915607
PMCPMC10616557
OpenAlexW4387409133

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.