Evidence map›Paper›PMID 37916874›Full record

ArticleThe EMBO journal2023

Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4

Daniele Canarutto, Claudia Asperti, Valentina Vavassori, Simona Porcellini, Elisabetta Rovelli, Marianna Paulis, Samuele Ferrari, Angelica Varesi, Martina Fiumara, Aurelien Jacob and 9 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. A precision gene-engineered B cell medicine producing sustained levels of active factor IX for hemophilia B therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Daniele CanaruttoSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-6999-8479
Claudia AspertiSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0009-0007-5337-4507
Valentina VavassoriSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-3805-0420
Simona PorcelliniSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0009-0002-6179-6287
Elisabetta RovelliSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marianna PaulisHumanitas Clinical and Research Center IRCCS, Milan, Italy.ORCID 0000-0001-7803-9982
Samuele FerrariSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-1122-1231
Angelica VaresiSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-1246-2320
Martina FiumaraSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0009-0007-5934-9273
Aurelien JacobSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-4799-3711
Lucia Sergi SergiSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ilaria VisigalliSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesca FerruaSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-5695-4490
Luis Ignacio González-GranadoUnidad de Immunodeficiencias Primarias y la Unidad de Hematología y Oncología Pediátrica, Instituto de Investigacíon Hospital 12 de Octubre, Madrid, Spain.ORCID 0000-0001-6917-8980
Vassilios LougarisUniversity of Brescia, Brescia, Italy.ORCID 0000-0003-2303-9533
Andrea FinocchiAcademic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, Bambino Gesú Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Anna VillaSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-4428-9013
Marina RadrizzaniSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-0641-4805
Luigi NaldiniSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-7835-527X
The San Raffaele Telethon Institute for Gene Therapy · ITVita-Salute San Raffaele University · ITBambino Gesù Children's Hospital · ITHumanitas University · ITInstitute of Genetic and Biomedical Research · ITResearch Institute Hospital 12 de Octubre · ESUniversity of Brescia · IT

Funding

E-Rare JTC-2017/EDSCIDFondazione Telethon ETS TTPGE0322TTGenespire Srl GENESPIRE.E
6 · The paper itself

Abstract

Hyper IgM1 is an X-linked combined immunodeficiency caused by CD40LG mutations, potentially treatable with CD4

Indexed as

CRISPR-Cas SystemsGene EditingCD4-Positive T-LymphocytesGenomeHumansT-LymphocytesAAV6CRISPRIDLVlarge deletionslarge integrations

Identifiers

PMID37916874
PMCPMC10690452
OpenAlexW4388233220

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.