Evidence map›Paper›PMID 37917212›Full record

ArticleDigestive diseases and sciences2024

Identification of Molecular Targets of Bile Acids Acting on Colorectal Cancer and Their Correlation with Immunity.

Xi Yang, Ping Li, Jing Zhuang, Yinhang Wu, Zhanbo Qu, Wei Wu, Qichun Wei

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xi YangHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China.
Ping LiThe Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Jing ZhuangHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China.
Yinhang WuHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China.
Zhanbo QuHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China.
Wei WuHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China.
Qichun WeiHuzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang, People's Republic of China. qichun_wei@zju.edu.cn.ORCID http://orcid.org/0000-0002-8688-5000
Zhejiang Chinese Medical University · CNHuzhou Central Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

Natural Science Foundation of Zhejiang Province No.LQ23H160006Zhejiang Medical and Health Technology Project No. 2021KY343Zhejiang Medical and Health Technology Project No. 2022KY1220
6 · The paper itself

Abstract

backgroundBile acids (BAs) are closely related to the occurrence and development of colorectal cancer (CRC), but the specific mechanism is still unclear.

aimsTo identify potential targets related to BAs in CRC and analyze the correlation with immunity.

methodsThe expression of BAs and CRC-related genes in TCGA was studied and screened using KEGG. GSE71187 was used for external validation of differentially expressed genes. Immunofluorescence, immunohistochemistry, and enzymatic cycling assays were used to detect the expression levels of the differentially expressed genes ki67 and BAs. Weighted gene coexpression network analysis (WGCNA) was used to identify genes associated with differential gene expression and immunity. The Cibersort algorithm was used to detect the infiltration of 22 kinds of immune cells in cancer tissues. The PPI network and ceRNA network were constructed to reveal the possible molecular mechanisms behind tumorigenesis.

resultsThe BA-related gene UGT2A3 is positively correlated with good prognoses in CRC. The expression level of UGT2A3 was negatively related to the BA level and positively related to the Ki67 proliferation index. The expression level of UGT2A3 was higher in the moderately differentiation and advanced stage (stage IV) of CRC. In addition, the expression level of UGT2A3 is correlated with CD8+ T cells. A PPI network related to UGT2A3 and T-cell immune-related genes was constructed. A ceRNA network containing 32 miRNA‒mRNA and 40 miRNA‒lncRNA regulatory pairs was constructed.

conclusionUGT2A3 is a potential molecular target of bile acids in the regulation of CRC and is related to T-cell immunity.

Indexed as

Colorectal NeoplasmsMicroRNAsAlgorithmsBile Acids and SaltsHumansKi-67 AntigenBile Acids and SaltsKi-67 AntigenMicroRNAsBile acidsColorectal cancerImmunityT cellUGT2A3

Identifiers

PMID37917212
OpenAlexW4388221028

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.