ArticleMaterials today. Bio2023
3D-printed PCL scaffolds with anatomy-inspired bionic stratified structures for the treatment of growth plate injuries.
Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Growth Plate Injuries: Advances and Future Directions in Regenerative Medicine.Annals of biomedical engineering · 2026Review
- Pediatric physeal repair: from immune-angiogenic-osteogenic coupling to zonal biomimetic scaffolds.Frontiers in cell and developmental biology · 2026Review
- The cutting-edge advancements in biomaterials under the guidance of intelligence and bionics.Regenerative biomaterials · 2026Review
- Current status, trend and progress of stem cells in tracheal tissue engineering research: an overview and perspectives.Stem cell research & therapy · 2025Review
- Fabrication of poly (ɛ-caprolactone) 3D scaffolds with controllable porosity using ultrasound.Scientific reports · 2025Article
- Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering.Materials today. Bio · 2025Review
- Bioengineered tracheal graft with enhanced vascularization and mechanical stability for functional airway reconstruction.Regenerative therapy · 2025Review
- Advances in tissue engineering for the repair of growth plate injuries.Frontiers in bioengineering and biotechnology · 2025Review
- Short histological kaleidoscope - recent findings in histology. Part V. About tendons, ligaments, and cartilages.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growth plate is a cartilaginous tissue with three distinct zones. Resident chondrocytes are highly organized in a columnar structure, which is critical for the longitudinal growth of immature long bones. Once injured, the growth plate may potentially be replaced by bony bar formation and, consequently, cause limb abnormalities in children. It is well-known that the essential step in growth plate repair is the remolding of the organized structure of chondrocytes. To achieve this, we prepared an anatomy-inspired bionic Poly(ε-caprolactone) (PCL) scaffold with a stratified structure using three-dimensional (3D) printing technology. The bionic scaffold is engineered by surface modification of NaOH and collagen Ⅰ (COL Ⅰ) to promote cell adhesion. Moreover, chondrocytes and bone marrow mesenchymal stem cells (BMSCs) are loaded in the most suitable ratio of 1:3 for growth plate reconstruction. Based on the anatomical structure of the growth plate, the bionic scaffold is designed to have three regions, which are the small-, medium-, and large-pore-size regions. These pore sizes are used to induce BMSCs to differentiate into similar structures such as the growth plate. Remarkably, the X-ray and histological results also demonstrate that the cell-loaded stratified scaffold can successfully rebuild the structure of the growth plate and reduce limb abnormalities, including limb length discrepancies and angular deformities
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