Evidence map›Paper›PMID 37923824›Full record

ArticlePharmacological reports : PR2023

Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT

Magdalena Zaniewska, Natalia Alenina, Sebastian Fröhler, Wei Chen, Michael Bader

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. The Effect of Serotonin 5-HTAddiction biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 3 countries.

Magdalena ZaniewskaDepartment of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland. zaniew@if-pan.krakow.pl.ORCID http://orcid.org/0000-0001-9716-6661
Natalia AleninaMax-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Sebastian FröhlerLaboratory for New Sequencing Technology, Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Wei ChenLaboratory for New Sequencing Technology, Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Michael BaderMax-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Max Delbrück Center · DE

Funding

H2020 Marie Skłodowska-Curie Actions N 953327Ministerstwo Edukacji i Nauki 632/MOB/2011/0
6 · The paper itself

Abstract

backgroundSerotonin (5-HT) 5-HT

methodsWe used deep sequencing to investigate 5-HT

resultsCessation from chronic 10% ethanol exposure in a two-bottle choice paradigm enhanced immobility time and decreased latency in the forced swim test (FST), indicating a depression-like phenotype. In the hippocampus, ethanol-deprived "high ethanol-drinking" mice displayed reduced Tph2 expression, elevated 5-HT

conclusionsOur findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT

Indexed as

Receptor, Serotonin, 5-HT2CSerotoninAnimalsBrainEthanolMiceRNA, MessengerEthanolReceptor, Serotonin, 5-HT2CRNA, MessengerSerotonin5-HT2C receptor mRNA editingDeep sequencingEthanol cessationMiceTph2 knockoutTph2 transcript level

Identifiers

PMID37923824
PMCPMC10661786
OpenAlexW4388287909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.