ArticleCell reports2023
Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Linking functional and structural dendritic spine remodeling during fear learning and extinction in vivo.Science advances · 2026Article
- Closed-Loop Connectivity Best Supports Angular Tuning and Sleep Dynamics in a Biophysical Thalamocortical Circuit Model.bioRxiv : the preprint server for biology · 2025Article
- A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations.Network neuroscience (Cambridge, Mass.) · 2025Article
- Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework.PLoS computational biology · 2024Article
- Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity.PLoS computational biology · 2024Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.Communications biology · 2024Article
- Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference.PLoS computational biology · 2024Article
- Simulations predict differing phase responses to excitation vs. inhibition in theta-resonant pyramidal neurons.Journal of neurophysiology · 2023Article
- Simulations of cortical networks using spatially extended conductance-based neuronal models.The Journal of physiology · 2023Review
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study.PLoS computational biology · 2023Article
- Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference.bioRxiv : the preprint server for biology · 2023Article
- Laminar Specificity of the Auditory Perceptual Awareness Negativity: A Biophysical Modeling Study.bioRxiv : the preprint server for biology · 2023Article
- The effect of alterations of schizophrenia-associated genes on gamma band oscillations.Schizophrenia (Heidelberg, Germany) · 2022Article
- Modernizing the NEURON Simulator for Sustainability, Portability, and Performance.Frontiers in neuroinformatics · 2022Article
- Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE.Frontiers in neuroinformatics · 2022Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
We developed a detailed model of macaque auditory thalamocortical circuits, including primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus, utilizing the NEURON simulator and NetPyNE tool. The A1 model simulates a cortical column with over 12,000 neurons and 25 million synapses, incorporating data on cell-type-specific neuron densities, morphology, and connectivity across six cortical layers. It is reciprocally connected to the MGB thalamus, which includes interneurons and core and matrix-layer-specific projections to A1. The model simulates multiscale measures, including physiological firing rates, local field potentials (LFPs), current source densities (CSDs), and electroencephalography (EEG) signals. Laminar CSD patterns, during spontaneous activity and in response to broadband noise stimulus trains, mirror experimental findings. Physiological oscillations emerge spontaneously across frequency bands comparable to those recorded in vivo. We elucidate population-specific contributions to observed oscillation events and relate them to firing and presynaptic input patterns. The model offers a quantitative theoretical framework to integrate and interpret experimental data and predict its underlying cellular and circuit mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.