Evidence map›Paper›PMID 37926971›Full record

ArticleTraffic (Copenhagen, Denmark)2024

Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum.

Mikha Gabriela, Claudia B G Barnes, Dickson Leong, Brad E Sleebs, Molly Parkyn Schneider, Dene R Littler, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Traffic (Copenhagen, Denmark), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mikha GabrielaMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0001-8983-9790
Claudia B G BarnesMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.
Dickson LeongMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.
Brad E SleebsThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Molly Parkyn SchneiderMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-5491-5455
Dene R LittlerInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Brendan S CrabbMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.
Tania F de Koning-WardSchool of Medicine, Deakin University, Geelong, Victoria, Australia.
Paul R GilsonMalaria Virulence and Drug Discovery Group, Burnet Institute, Melbourne, Victoria, Australia.
Burnet Institute · AUAustralian Regenerative Medicine Institute · AUDeakin University · AUThe University of Melbourne · AU

Funding

Australian Research Council DP160102582NHMRC 1092789NHMRC 119780521Victorian Operational Infrastructure Support Program
6 · The paper itself

Abstract

The parasite Plasmodium falciparum causes the most severe form of malaria and to invade and replicate in red blood cells (RBCs), it exports hundreds of proteins across the encasing parasitophorous vacuole membrane (PVM) into this host cell. The exported proteins help modify the RBC to support rapid parasite growth and avoidance of the human immune system. Most exported proteins possess a conserved Plasmodium export element (PEXEL) motif with the consensus RxLxE/D/Q amino acid sequence, which acts as a proteolytic cleavage recognition site within the parasite's endoplasmic reticulum (ER). Cleavage occurs after the P

Indexed as

ParasitesPlasmodiumAnimalsErythrocytesHumansPlasmodium falciparumProtein TransportProtozoan ProteinsProtozoan ProteinschaperonemalariaPEXELPlasmodium falciparumprotein exportPTEXvirulence

Identifiers

PMID37926971
PMCPMC10952997
OpenAlexW4388419275

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.