Evidence map›Paper›PMID 37929291›Full record

ArticleBiochemistry and biophysics reports2023

Engineering neuroglobin nitrite reductase activity based on myoglobin models.

Mark D Williams, Venkata Ragireddy, Matthew R Dent, Jesús Tejero

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Cytochrome bFree radical biology & medicine · 2026
    Article
  2. Article
  3. CytochromebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mark D WilliamsHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Venkata RagireddyHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Matthew R DentHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Jesús TejeroHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
University of Pittsburgh · US

Funding

Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsK99HL168224 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2023 to 2024
$326k
Development of a carbon monoxide scavenging hemoprotein as a novel antidotal therapy to treat inhaled CO poisoningF32HL162381 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2022 to 2022
$77k
NHLBI NIH HHS F32 HL162381NHLBI NIH HHS K99 HL168224NHLBI NIH HHS R01 HL125886
6 · The paper itself

Abstract

Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate heme as compared to the pentacoordinated heme of myoglobin and hemoglobin. While several reactions of neuroglobin have been characterized

Indexed as

NeuroglobinNitric oxideNitrite reductionProtein engineering

Identifiers

PMID37929291
PMCPMC10623171
OpenAlexW4387842795

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.