Evidence map›Paper›PMID 37929565›Full record

ArticleCirculation2024

Nonischemic or Dual Cardiomyopathy in Patients With Coronary Artery Disease.

Parag Bawaskar, Nicholas Thomas, Khaled Ismail, Yugene Guo, Sanya Chhikara, Pal Satyajit Singh Athwal, Alison Ranum, Achal Jadhav, Abel Hooker Mendez, Ishan Nadkarni and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential.International journal of cardiology. Heart & vasculature · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Stress cardiovascular magnetic resonance imaging in intermediate-risk emergency department patients with abnormal high-sensitivity troponin.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Parag BawaskarCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-9381-4294
Nicholas ThomasCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0009-0003-7050-0182
Khaled IsmailCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).
Yugene GuoCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-9110-1442
Sanya ChhikaraCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-3950-6290
Pal Satyajit Singh AthwalCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0003-0285-1995
Alison RanumCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).
Achal JadhavCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0009-0002-6032-9249
Abel Hooker MendezCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0009-0004-4830-5468
Ishan NadkarniCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).
Dominic FrerichsCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-5520-1251
Pratik VelangiCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0001-9171-2422
Tesfatsiyon ErgandoCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-3039-5045
Hassan AkramCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).
Adinan KandaCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0002-8041-8006
Chetan ShenoyCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (P.B., N.T., K.I., Y.G., S.C., P.S.S.A., A.R., A.J., A.H.M., I.N., D.F., P.V., T.E., H.A., A.K., C.S.).ORCID 0000-0001-8877-4999
Anna Needs Neuroblastoma Answers · US

Funding

Immunologic basis of cardiac disease after severe COVID-19R01HL158756 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$663k
NHLBI NIH HHS K23 HL132011NHLBI NIH HHS R01 HL158756NHLBI NIH HHS R03 HL157011
6 · The paper itself

Abstract

backgroundRandomized trials in obstructive coronary artery disease (CAD) have largely shown no prognostic benefit from coronary revascularization. Although there are several potential reasons for the lack of benefit, an underexplored possible reason is the presence of coincidental nonischemic cardiomyopathy (NICM). We investigated the prevalence and prognostic significance of NICM in patients with CAD (CAD-NICM).

methodsWe conducted a registry study of consecutive patients with obstructive CAD on coronary angiography who underwent contrast-enhanced cardiovascular magnetic resonance imaging for the assessment of ventricular function and scar at 4 hospitals from 2004 to 2020. We identified the presence and cause of cardiomyopathy using cardiovascular magnetic resonance imaging and coronary angiography data, blinded to clinical outcomes. The primary outcome was a composite of all-cause death or heart failure hospitalization, and secondary outcomes were all-cause death, heart failure hospitalization, and cardiovascular death.

resultsAmong 3023 patients (median age, 66 years; 76% men), 18.2% had no cardiomyopathy, 64.8% had ischemic cardiomyopathy (CAD+ICM), 9.3% had CAD+NICM, and 7.7% had dual cardiomyopathy (CAD+dualCM), defined as both ICM and NICM. Thus, 16.9% had CAD+NICM or dualCM. During a median follow-up of 4.8 years (interquartile range, 2.9, 7.6), 1116 patients experienced the primary outcome. In Cox multivariable analysis, CAD+NICM or dualCM was independently associated with a higher risk of the primary outcome compared with CAD+ICM (adjusted hazard ratio, 1.23 [95% CI, 1.06-1.43];

conclusionsIn patients with CAD referred for clinical cardiovascular magnetic resonance imaging, NICM or dualCM was identified in 1 of every 6 patients and was associated with worse long-term outcomes compared with ICM. In patients with obstructive CAD, coincidental NICM or dualCM may contribute to the lack of prognostic benefit from coronary revascularization.

Indexed as

CardiomyopathiesCoronary Artery DiseaseHeart FailureMyocardial IschemiaAgedFemaleHumansMalePrognosiscardiac magnetic resonance imagingcoronary artery diseasedual cardiomyopathyetiologyischemic cardiomyopathynonischemic cardiomyopathyoutcomesprognosis

Identifiers

PMID37929565
PMCPMC10951941
OpenAlexW4388421130

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.