ArticleCirculation research2023
Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.
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Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31citing papers in PubMed, 1 pooled it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Immunology of heart failure with preserved ejection fraction.Expert review of clinical immunology · 2025Pooled it
- Myeloid Cell Expansion Propels Right Ventricular Dysfunction in HFpEF Through Sterile Inflammation.Circulation · 2026Article
- Bellidifolin Improves Pulmonary Artery Smooth Muscle Cells Proliferation by Targeting the IGFBP5-Mediated PI3K-AKT-mTOR Pathway and Dilates the Pulmonary Artery.Biomolecules · 2026Article
- Heart-Lung Interactions in Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction.Comprehensive physiology · 2026Review
- Advances in the pathogenesis and clinical management of pulmonary hypertension.Medical review (2021) · 2026Review
- Comorbidity-Driven Inflammation in HFpEF: Immune Profiling and Therapeutic Targets.Current heart failure reports · 2026Review
- Arterio-venous gradient of active interleukin-18 is associated with diastolic dysfunction: a cross-sectional study.ESC heart failure · 2026Article
- Review
- Evaluation of pulmonary hypertension in heart failure with preserved ejection fraction.Heart failure reviews · 2025Review
- Systemic Interactions in HFpEF: A Multiorgan Perspective on Pathways and Therapeutic Targets.Journal of cardiovascular translational research · 2025Review
- Early pathological changes of coronary microvasculation in heart failure with preserved ejection fraction.BMC cardiovascular disorders · 2025Article
- Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation.bioRxiv : the preprint server for biology · 2025Article
- Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF.bioRxiv : the preprint server for biology · 2025Article
- Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension.Cardiovascular diabetology · 2025Article
- Hemodynamic Definitions, Phenotypes, Pathophysiology, and Evaluation of Pulmonary Hypertension Related to Left Heart Disease.Journal of cardiovascular development and disease · 2025Review
- New insights into pulmonary arterial hypertension: interaction between PANoptosis and perivascular inflammatory responses.Apoptosis : an international journal on programmed cell death · 2025Review
- Potential Role of SESN3 in Linking Heart Failure with Preserved Ejection Fraction and Chronic Obstructive Pulmonary Disease via Autophagy Dysregulation.International journal of molecular sciences · 2025Article
- Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren's Syndrome Related Dry Eye.Investigative ophthalmology & visual science · 2025Article
- Housing temperature influences metabolic phenotype of heart failure with preserved ejection fraction in J vs N strain C57BL/6 mice.Molecular and cellular endocrinology · 2025Article
- Macrophages in ventricular remodeling and heart failure: orchestrators of inflammation and repair.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Vineet AgrawalDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-8457-6722
Jonathan A KropskiDivision of Pulmonary, Allergy, and Critical Care (J.A.K., J.J.G., C.S.M., T.B., M.H.T., S.G., E.J.C., J.D.W., A.R.H., N.L.F.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-8923-1344
Jason J GokeyDivision of Pulmonary, Allergy, and Critical Care (J.A.K., J.J.G., C.S.M., T.B., M.H.T., S.G., E.J.C., J.D.W., A.R.H., N.L.F.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8244-7831
Elizabeth KobeckDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Matthew B MurphyDivision of Clinical Pharmacology (M.B.M., K.T.M., K.T.M.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Katherine T MurrayDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-1342-4457
Niki L FortuneDivision of Pulmonary, Allergy, and Critical Care (J.A.K., J.J.G., C.S.M., T.B., M.H.T., S.G., E.J.C., J.D.W., A.R.H., N.L.F.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Christy S MooreDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
David F MeoliDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Ken MonahanDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-1650-4647
Yan Ru SuDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Thomas BlackwellDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Deepak K GuptaDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Megha H TalatiDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Santhi GladsonDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Erica J CarrierDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-3363-3088
James D WestDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Anna R HemnesDivision of Cardiovascular Medicine (V.A., E.K., K.T.M., D.F.M., K.M., Y.R.S., D.K.G.), Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2755-5845
Vanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MSex Hormones in Pulmonary Arterial HypertensionP01HL108800 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWMAN, JOHN HUGHES · 2012 to 2021
$22.0MSpatiotemporal genomic regulation of disease initiation and progression in pulmonary fibrosisR01HL145372 · NHLBI · TRANSLATIONAL GENOMICS RESEARCH INST · PI Nicholas Eli Banovich, Jonathan Andrew Kropski · 2019 to 2026
$6.0MMechanisms of epithelial repair and remodeling in pulmonary fibrosisR01HL153246 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KROPSKI, JONATHAN ANDREW · 2020 to 2024
$2.8MMentorship in Pulmonary Vascular DiseaseK24HL155891 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Anna R Hemnes · 2022 to 2026
$573kA Pathogenic Role for Natriuretic Peptide Receptor-C in Pulmonary Hypertension and Heart Failure with Preserved Ejection FractionK08HL153956 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AGRAWAL, VINEET · 2021 to 2022
$317kA Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.IK2BX005828 · VA · VETERANS HEALTH ADMINISTRATION · PI Vineet Agrawal · 2023 to 2026
–BLRD VA IK2 BX005828NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K08 HL153956NHLBI NIH HHS K24 HL155891NHLBI NIH HHS P01 HL108800NHLBI NIH HHS R01 HL145372NHLBI NIH HHS R01 HL153246
Abstract
backgroundPulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted murine model of HFpEF also displays features of PH, and we sought to identify pathways that might drive early remodeling of the pulmonary vasculature in HFpEF.
methodsEight-week-old male and female C57BL/6J mice received either N
resultsN
conclusionsWe report a novel model for the study of PH and right heart remodeling in HFpEF, and we identify myeloid cell-derived IL-1β as an important contributor to PH in HFpEF.
Indexed as
Heart FailureHypertension, PulmonaryAnimalsClodronic AcidFemaleHumansInterleukin-1betaMaleMiceMice, Inbred C57BLMyeloid CellsStroke VolumeClodronic AcidIL1B protein, mouseInterleukin-1betacytokinesheart failurehypertension, pulmonarymacrophagesmyeloid cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.