Evidence map›Paper›PMID 37932721›Full record

ArticleThe journal of headache and pain2023

Serum neurofilament light chain levels in migraine patients: a monocentric case-control study in China.

Jie Fang, Jielong Wu, Tengkun Zhang, Xiaodong Yuan, Jiedong Zhao, Liangcheng Zheng, Ganji Hong, Lu Yu, Qing Lin, Xingkai An and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of soluble biomarkers in treating multiple sclerosis and neuroinflammatory conditions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Plasma levels of glial fibrillary acidic protein and neurofilament light chain in patients with chronic migraine: a multicenter case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Jie Fang *Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Jielong Wu *Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Tengkun Zhang *Department of Neurology, The Fifth Hospital of Xiamen, Xiamen, China.
Xiaodong YuanDepartment of Gynecology, Xiamen Maternal and Child Health Care Hospital, Xiamen, China.
Jiedong ZhaoThe School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Liangcheng ZhengDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Ganji HongCerebrovascular Interventional Department, Zhangzhou Hospital of Fujian Province, Zhangzhou, China.
Lu YuDepartment of Neurology, Changxing People's Hospital, Huzhou, China.
Qing LinDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Xingkai AnDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Chuya JingDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Qiuhong ZhangDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Chen WangDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.
Zhanxiang WangThe School of Clinical Medicine, Fujian Medical University, Fuzhou, China. wangzx@xmu.edu.cn.
Qilin MaDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China. qilinma@yeah.net.
First Affiliated Hospital of Xiamen University · CNXiamen Blood Center · CNFifth Hospital of Shijiazhuang · CNFujian Medical University · CNXiamen Maternal and Child Health Hospital · CNXiamen University · CNZhangzhou Municipal Hospital of Fujian Province · CN

Funding

Key Project of Natural Science Foundation of Fujian Province 2021J02057Medical and Health Key Project of Xiamen 3502Z20204006Natural Science Foundation of China 82072777Natural Science Foundation of Fujian Province 2020J02063Natural Science Foundation of Fujian Province 2022J011358Natural Science Foundation of Fujian Province 2022J011365Xiamen Municipal Health Commission, Xiamen Municipal Bureau of Science and Technology 3502Z20209005
6 · The paper itself

Abstract

purposeSerum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine.

methodsA case-control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics.

resultsOverall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels.

conclusionsThis is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required.

Indexed as

Intermediate FilamentsMigraine DisordersAdultBiomarkersCase-Control StudiesChinaFemaleHumansMaleBiomarkersMigraineMigraine disease courseNeurological damageSerum neurofilament light chain

Identifiers

PMID37932721
PMCPMC10626745
OpenAlexW4388414969

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.