Evidence map›Paper›PMID 37932782›Full record

ArticleBehavioral and brain functions : BBF2023

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats.

Elena Martín-González, Ángeles Prados-Pardo, Stephen J Sawiak, Jeffrey W Dalley, Daniel Padro, Pedro Ramos-Cabrer, Santiago Mora, Margarita Moreno-Montoya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral and brain functions : BBF, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Elena Martín-GonzálezDepartment of Psychology and Health Research Centre (CEINSA), University of Almería, Carretera de Sacramento s/n, 04120, Almería, Spain.
Ángeles Prados-PardoDepartment of Psychology and Health Research Centre (CEINSA), University of Almería, Carretera de Sacramento s/n, 04120, Almería, Spain.
Stephen J SawiakDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Cambridge, UK.
Daniel PadroCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, Donostia-San Sebastián, Spain.
Pedro Ramos-CabrerCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, Donostia-San Sebastián, Spain.
Santiago MoraDepartment of Neuroscience, University of Copenhagen Panum Institute, Copenhagen, Denmark.
Margarita Moreno-MontoyaDepartment of Psychology and Health Research Centre (CEINSA), University of Almería, Carretera de Sacramento s/n, 04120, Almería, Spain. mgmoreno@ual.es.
University of Almería · ESCIC biomaGUNE · ESUniversity of Cambridge · GBUniversity of Copenhagen · DK

Funding

FEDER I+D+I "una manera de hacer Europa" UAL2020-CTSD2068Ministerio de Ciencia e Innovación PID2022-139286NB-I00Plan Nacional sobre Drogas PND-2022l024
6 · The paper itself

Abstract

Compulsivity is considered a transdiagnostic dimension in obsessive-compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans.

Indexed as

BrainCompulsive BehaviorAmygdalaAnimalsBasal GangliaBrain MappingHumansMagnetic Resonance ImagingMalePhenotypeRatsCompulsive behaviorCortico-striatal-thalamic-cortical circuitMagnetic resonance imagingSchedule-Induced PolydipsiaVoxel-based morphometryWhite matter

Identifiers

PMID37932782
PMCPMC10626819
OpenAlexW4388413140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.