Evidence map›Paper›PMID 37933628›Full record

ReviewFuture cardiology2023

Mesenchymal STRO-1/STRO-3

Andrew Sundin, Simona I Ionescu, Wayne Balkan, Joshua M Hare

Abstract readReview
In one paragraph

Review in Future cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew SundinInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-9539-1248
Simona I IonescuInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0009-4271-8751
Wayne BalkanInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-0405-0489
Joshua M HareInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-7751-5032

Funding

Mesenchymal stem cell therapy for endothelial dysfunction in diabetesR01HL134558 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2016 to 2020
$3.2M
NHLBI NIH HHS 1R01HL134558NHLBI NIH HHS R01 HL134558
6 · The paper itself

Abstract

The heart is susceptible to proinflammatory and profibrotic responses after myocardial injury, leading to further worsening of cardiac dysfunction. Important developments in the management of heart failure with reduced ejection fraction have reduced morbidity and mortality; however, these therapies focus on optimizing cardiac function through hemodynamic and neurohormonal pathways and not by repairing the underlying cardiac injury. The potential of cell-based therapy to reverse cardiac injury has received substantial attention. Herein are examined the phase II and III studies of bone marrow-derived mesenchymal STRO-1

Indexed as

Heart FailureMesenchymal Stem Cell TransplantationVentricular Dysfunction, LeftChronic DiseaseHumansStroke Volumeheart failuremesenchymal cellsmesoblastmyocardial regenerationreduced ejection fractionstem cellstem cell therapy

Identifiers

PMID37933628
PMCPMC10652293

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.