Evidence map›Paper›PMID 37937211›Full record

ArticleOncoimmunology2023

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia.

Iria Fernandez Botana, Giulia Pagano, Etienne Moussay, Jerome Paggetti

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Iria Fernandez BotanaTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.
Giulia PaganoTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.
Etienne MoussayTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.ORCID 0000-0002-0879-8067
Jerome PaggettiTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.ORCID 0000-0001-9460-5876
Luxembourg Institute of Health · LUUniversity of Luxembourg · LU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Indexed as

Interleukin-27Leukemia, Lymphocytic, Chronic, B-CellAdultCytokinesHumansImmunosuppression TherapyT-LymphocytesCytokinesInterleukin-27CD8+ T cellsCytokineIL-27immunotherapyleukemia

Identifiers

PMID37937211
PMCPMC10627055
OpenAlexW4388289791

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.