Evidence map›Paper›PMID 37937585›Full record

ArticleJournal of diabetes science and technology2025

The Role of Ultra-Rapid-Acting Insulin Analogs in Diabetes: An Expert Consensus.

Francesco Giorgino, Tadej Battelino, Richard M Bergenstal, Thomas Forst, Jennifer B Green, Chantal Mathieu, Helena W Rodbard, Oliver Schnell, Emma G Wilmot

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Journal of diabetes science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 6 countries.

Francesco GiorginoSection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.ORCID 0000-0001-7372-2678
Tadej BattelinoDepartment of Endocrinology, Diabetes and Metabolism, UCH-University Medical Center Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-0273-4732
Richard M BergenstalInternational Diabetes Center at Park Nicollet, Minneapolis, MN, USA.ORCID 0000-0002-9050-5584
Thomas ForstDepartment of Endocrinology and Metabolic Diseases, Johannes Gutenberg University Medical Center, Mainz, Germany.
Jennifer B GreenDivision of Endocrinology and Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Chantal MathieuClinical and Experimental Endocrinology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
Helena W RodbardEndocrine and Metabolic Consultants, Rockville, MD, USA.
Oliver SchnellForschergruppe Diabetes eV at the Helmholtz Centre, Munich-Neuherberg, Germany.ORCID 0000-0003-4968-2367
Emma G WilmotDepartment of Diabetes & Endocrinology, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Duke University · USHelmholtz Zentrum München · DEJohannes Gutenberg University Mainz · DEKU Leuven · BEPark Nicollet Clinic · USUniversity of Bari Aldo Moro · ITUniversity of Ljubljana · SIUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultra-rapid-acting insulin analogs (URAA) are a further development and refinement of rapid-acting insulin analogs. Because of their adapted formulation, URAA provide an even faster pharmacokinetics and thus an accelerated onset of insulin action than conventional rapid-acting insulin analogs, allowing for a more physiologic delivery of exogenously applied insulin. Clinical trials have confirmed the superiority of URAA in controlling postprandial glucose excursions, with a safety profile that is comparable to the rapid-acting insulins. Consequently, many individuals with diabetes mellitus may benefit from URAA in terms of prandial glycemic control. Unfortunately, there are only few available recommendations from authoritative sources for use of URAA in clinical practice. Therefore, this expert consensus report aims to define populations of people with diabetes mellitus for whom URAA may be beneficial and to provide health care professionals with concrete, practical recommendations on how best to use URAA in this context.

Indexed as

Diabetes MellitusDiabetes Mellitus, Type 2Hypoglycemic AgentsInsulin, Short-ActingBlood GlucoseHumansBlood GlucoseHypoglycemic AgentsInsulin, Short-Actingfaster aspartinsulin therapytype 1 diabetestype 2 diabetesultra-rapid-acting insulinURLi

Identifiers

PMID37937585
PMCPMC11874134
OpenAlexW4388492496

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.