Evidence map›Paper›PMID 37938467›Full record

ArticleJournal of materials science. Materials in medicine2023

A novel degradable PCL/PLLA strapping band for internal fixation of fracture.

Baoyan Jin, Chongjing Zhang, Zeyuan Zhong, Zichen Liu, Zhenhua Zhang, Dejian Li, Min Zhu, Baoqing Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Baoyan Jin *School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Chongjing Zhang *Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Zeyuan Zhong *Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Zichen LiuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Zhenhua ZhangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Dejian LiDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. lidejian880820@163.com.
Min ZhuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China. mzhu@usst.edu.cn.
Baoqing YuDepartment of Orthopedics, Shanghai Pudong New Area People's Hospital, Shanghai, China. doctorybq@163.com.
University of Shanghai for Science and Technology · CNFudan University · CNPudong Medical Center · CN

Funding

the Outstanding Clinical Discipline Project of Shanghai Pudong PWYgy2021-08
6 · The paper itself

Abstract

Early fracture fixation is the critical factor in fracture healing. Common internal fracture implants are made of metallic materials, which often affects the imaging quality of CT and MRI. Most patients will choose secondary surgery to remove the internal fixation implants, which causes secondary damage to them. The development of new degradable internal fracture implants has attracted more and more attention from orthopedic surgeons and researchers. Based on these problems, we improved the various properties of medical grade polycaprolactone (PCL) by adding poly(L-lactide) (PLLA). We produced PCL/PLLA strapping bands with different mass ratios by injection molding. We compared the mechanical properties, degradation properties, cell biocompatibility, bone marrow mesenchymal stem cells (BMSCs) adhesion, proliferation, osteogenic differentiation and fracture fixation effect of these strapping bands. The results showed that the tensile strength and yield force of the strapping bands increased with the increase of the content of PLLA. The addition of PLLA could significantly improve the mechanical strength in the early stage and accelerate the degradation rate of the strapping band. PCL/PLLA (80/20) strapping band had no significant cytotoxicity toward rBMSCs and could promote osteogenic differentiation of rBMSCs. The strapping band could ensure femoral fracture healing of beagles in 3 months and didn't cause damage to the surrounding tissues and main organs. This study will provide some new insights into the biodegradable products of PCL/PLLA blends for internal fixation of fracture. We produced novel degradable PCL/PLLA strapping bands with different mass ratios by injection molding. We tested the biological safety of the prepared internal fixation strapping bands for fracture, such as cell experiment in vitro and animal experiment, and studied the degradation behavior in vitro. The strapping bands could ensure femoral fracture healing of beagles. This study will provide some new insights into the biodegradable products of PCL/PLLA blends for internal fixation of fracture. A Immunofluorescence staining of rBMSCs (live cells: green; dead cells: red). B Young's modulus change curve during strapping bands degradation. C The implantation process of strapping bands. D Micro-CT images of the beagle's fracture recovery after the operation.

Indexed as

Femoral FracturesOsteogenesisAnimalsBiocompatible MaterialsDogsFracture Fixation, InternalFracture HealingHumansBiocompatible Materials

Identifiers

PMID37938467
PMCPMC10632200
OpenAlexW4388499410

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.