ArticleNature communications2023
A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Sensory receptor expansion and neural accommodation in butterfly color vision.Science advances · 2026Article
- Evolution of compound eye cell types shapes visual behaviors acrossbioRxiv : the preprint server for biology · 2026Article
- Article
- Expanding the fly eye gene regulatory network: From Drosophila to the hoverfly Episyrphus balteatus.PLoS genetics · 2026Article
- Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025Article
- Sensory receptor expansion and neural accommodation in butterfly color vision.bioRxiv : the preprint server for biology · 2025Article
- TheFrontiers in neuroscience · 2025Article
- The astrocyte-enriched geneFly · 2024Article
- Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc.Nature communications · 2024Article
- A single cell RNA sequence atlas of the early Drosophila larval eye.BMC genomics · 2024Article
- A Closer Look at Histamine inInternational journal of molecular sciences · 2024Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila eye is a powerful model system to study the dynamics of cell differentiation, cell state transitions, cell maturation, and pattern formation. However, a high-resolution single cell genomics resource that accurately profiles all major cell types of the larval eye disc and their spatiotemporal relationships is lacking. Here, we report transcriptomic and chromatin accessibility data for all known cell types in the developing eye. Photoreceptors appear as strands of cells that represent their dynamic developmental timelines. As photoreceptor subtypes mature, they appear to assume a common transcriptomic profile that is dominated by genes involved in axon function. We identify cell type maturation genes, enhancers, and potential regulators, as well as genes with distinct R3 or R4 photoreceptor specific expression. Finally, we observe that the chromatin accessibility between cones and photoreceptors is distinct. These single cell genomics atlases will greatly enhance the power of the Drosophila eye as a model system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.