SynthesisArchives of disease in childhood2024
Infant fat mass and later child and adolescent health outcomes: a systematic review.
Synthesis in Archives of disease in childhood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Trial
- Body composition at 2 years of age in moderate and late preterm infants.Journal of pediatric gastroenterology and nutrition · 2026Article
- Temporal Dynamics of the Milk Proteome in Women with Gestational Diabetes Mellitus.Journal of proteome research · 2026Article
- Early-Life Nutritional Determinants of Pediatric MASLD.Nutrients · 2025Review
- Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age.Pediatric research · 2025Article
- Alterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy.Pediatric research · 2025Article
- The role of prenatal maternal sex steroid hormones in weight and adiposity at birth and growth trajectories during infancy.International journal of obesity (2005) · 2025Article
- Article
- Predictors influencing neurodevelopment during the infancy of term infants.Frontiers in pediatrics · 2025Article
- Waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children.Pediatric research · 2024Article
- The role of prenatal maternal sex steroid hormones in weight and adiposity at birth and growth trajectories during infancy.Research square · 2024Article
- Maternal organokines throughout pregnancy as predictors of neonatal anthropometric characteristics and adiposity.Frontiers in endocrinology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveObesity and excess adiposity are leading causes of metabolic and cardiovascular morbidity and mortality. Early identification of individuals at risk is key for preventive strategies. We examined the relationship between infant body composition (0-2 years of age) and later (>2 years) health outcomes using a systematic review.
designWe preregistered the study on PROSPERO (ID 288013) and searched Embase, PubMed and Cochrane databases for English language publications using the Medical Subject Headings (MeSH) terms 'infant' and 'body composition' and 'risk' between January 1946 and February 2022. We included studies which assessed infant body composition using predetermined in vivo methods other than body mass index (BMI).
resultsWe identified 6015 articles. After abstract screening to assess eligibility, we reviewed 130 full text publications. 30 were included in the final assessment and narrative synthesis. Meta-analysis was not possible due to heterogeneity of results. All 30 studies were of high quality and reported associations between infant body composition and 19 different health outcomes after 2 years of age. Outcome measurements ranged from 2 years to 16 years. The strongest associations were found between infant fat mass and later fat mass (7 studies), and later BMI (5 studies). For 11 of the outcomes assessed, there was no relationship to infant adiposity detected.
conclusionsCurrent evidence, from a small number of studies, suggests a positive association between infant adiposity and future adiposity or BMI, but the validity of infant body composition as a biomarker of future health remains inconclusive. Carefully designed, standardised studies are required to identify the value of infant body composition for predicting later health.
trial registrationPROSPERO: 288013.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.