Evidence map›Paper›PMID 37940587›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Hypothalamic Supramammillary Control of Cognition and Motivation.

Andrew J Kesner, Marjan Mozaffarilegha, Keerthi Thirtamara Rajamani, Yosuke Arima, Hala Harony-Nicolas, Yuki Hashimotodani, Hiroshi T Ito, Juan Song, Satoshi Ikemoto

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew J KesnerUnit on Motivation and Arousal, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892 andrew.kesner@nih.gov.
Marjan MozaffarileghaMax Planck Institute for Brain Research, Frankfurt am Main, Germany 60438.
Keerthi Thirtamara RajamaniAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10021.ORCID 0000-0001-7312-7182
Yosuke ArimaNeurocircuitry of Motivation Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0001-9004-8902
Hala Harony-NicolasDepartment of Psychiatry, Department of Neuroscience, Seaver Autism Center for Research and Treatment, Friedman Brain Institute, Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Yuki HashimotodaniGraduate School of Brain Science, Doshisha University, Kyotanabe, Kyoto Japan 610-0394.ORCID 0000-0001-6723-2736
Hiroshi T ItoMax Planck Institute for Brain Research, Frankfurt am Main, Germany 60438.ORCID 0000-0001-7726-0781
Juan SongDepartment of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599.ORCID 0000-0002-7836-343X
Satoshi IkemotoNeurocircuitry of Motivation Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0002-0732-7386

Funding

Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionR01MH122692 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2020 to 2024
$2.9M
Role of Cholecystokinin in the Dentate GyrusR01NS121300 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2025
$2.3M
Regulation and functional contribution of hypothalamic modified adult hippocampal neurogenesisR01MH132222 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.3M
Enhancing adult-born neurons to restore brain functions in Alzheimer's diseaseR01AG084207 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.1M
Neural circuit and brain system alterations underlying social recognition memory deficitsR01MH116108 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARONY-NICOLAS, HALA · 2019 to 2023
$2.1M
Understanding interactions between brain reward and sleep systems in driving maladaptive behaviorsZIAAA000455 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KESNER, ANDREW · 2022 to 2025
$2.1M
Glutamatergic neural circuit modulation for treating Alzheimer’s diseaseRF1AG071000 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2021
$1.9M
Role of TRIM9 in regulating neurogenesis-associated hippocampal functionsR21NS104530 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2018 to 2019
$428k
Targeting inhibitory neural network for treatment of Alzheimers diseaseR21AG058160 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2018 to 2019
$425k
Intramural NIH HHS ZIA AA000455NIA NIH HHS R01 AG084207NIA NIH HHS R21 AG058160NIA NIH HHS RF1 AG071000NIMH NIH HHS R01 MH116108NIMH NIH HHS R01 MH122692NIMH NIH HHS R01 MH132222NINDS NIH HHS R01 NS121300NINDS NIH HHS R21 NS104530
6 · The paper itself

Abstract

The supramammillary nucleus (SuM) is a small region in the ventromedial posterior hypothalamus. The SuM has been relatively understudied with much of the prior focus being on its connection with septo-hippocampal circuitry. Thus, most studies conducted until the 21st century examined its role in hippocampal processes, such as theta rhythm and learning/memory. In recent years, the SuM has been "rediscovered" as a crucial hub for several behavioral and cognitive processes, including reward-seeking, exploration, and social memory. Additionally, it has been shown to play significant roles in hippocampal plasticity and adult neurogenesis. This review highlights findings from recent studies using cutting-edge systems neuroscience tools that have shed light on these fascinating roles for the SuM.

Indexed as

Hypothalamus, PosteriorMotivationCognitionHippocampusTheta Rhythm

Identifiers

PMID37940587
PMCPMC10634554

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.