ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial.Scientific reports · 2025Trial
- From optical control to translational readiness: an evidence-tiered framework for optogenetics in neuromuscular and neurological disorders.Materials today. Bio · 2026Review
- At-Home BCI Rehabilitation Therapy for Chronic Upper Extremity Deficit After Stroke (BCI-REHAB): A Randomized Trial.Stroke (Hoboken, N.J.) · 2026Article
- Exploring Gray Matter Alterations in Post-Stroke Patients: A Structural Covariance Analysis.Brain and behavior · 2026Article
- A clinical roadmap for lateropulsion after stroke based on a realist review strategy.Clinical rehabilitation · 2026Review
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- Early Multimodal Motor Training After Stroke Promotes Motor Recovery and Whole-Brain Structural Remodeling.Journal of the American Heart Association · 2026Article
- Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.Nature communications · 2026Article
- Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks.Communications engineering · 2026Article
- Review
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation.BMC medicine · 2026Article
- Electroacupuncture-Induced Phrenic Nerve Stimulation for Poststroke Pneumonia: A Propensity Score Matching Analysis.BioMed research international · 2026Article
- Visual processing of manipulable objects in the ventral stream is modulated by parietal action systems.Brain communications · 2026Article
- Closed-loop brain-computer interfaces for post-stroke sensorimotor loop restoration.Frontiers in neuroscience · 2026Review
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Aquaporin-4 suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway.Frontiers in immunology · 2026Article
- Review
- Integrated neuroimaging and robotic rehabilitation in chronic stroke: Neural correlates and predictors of motor recovery.Experimental and therapeutic medicine · 2025Article
- Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Stroke is one of the most common causes of disability, and there are few treatments that can improve recovery after stroke. Therapeutic development has been hindered because of a lack of understanding of precisely how neural circuits are affected by stroke, and how these circuits change to mediate recovery. Indeed, some of the hypotheses for how the CNS changes to mediate recovery, including remapping, redundancy, and diaschisis, date to more than a century ago. Recent technological advances have enabled the interrogation of neural circuits with ever greater temporal and spatial resolution. These techniques are increasingly being applied across animal models of stroke and to human stroke survivors, and are shedding light on the molecular, structural, and functional changes that neural circuits undergo after stroke. Here we review these studies and highlight important mechanisms that underlie impairment and recovery after stroke. We begin by summarizing knowledge about changes in neural activity that occur in the peri-infarct cortex, specifically considering evidence for the functional remapping hypothesis of recovery. Next, we describe the importance of neural population dynamics, disruptions in these dynamics after stroke, and how allocation of neurons into spared circuits can restore functionality. On a more global scale, we then discuss how effects on long-range pathways, including interhemispheric interactions and corticospinal tract transmission, contribute to post-stroke impairments. Finally, we look forward and consider how a deeper understanding of neural circuit mechanisms of recovery may lead to novel treatments to reduce disability and improve recovery after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.