Evidence mapPaperPMID 37944652Full record

ArticleSteroids2024

Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo.

Noah K Babel, Brian J Feldman

Open access · hybridAbstract read
In one paragraph

Article in Steroids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Noah K BabelDepartment of Pediatrics, Division of Endocrinology, University of California, San Francisco (UCSF), San Francisco, CA, United States.
Brian J FeldmanDepartment of Pediatrics, Division of Endocrinology, University of California, San Francisco (UCSF), San Francisco, CA, United States. Electronic address: Brian.Feldman@ucsf.edu.
University of California, San Francisco · US

Funding

NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK114217NIDDK NIH HHS R01 DK132404
6 · The paper itself

Abstract

Our research used glucocorticoids as a medically relevant molecular probe to identify a previously unrecognized ADAMTS1-PTN-Wnt pathway. We elucidated the role of this pathway in regulating adipose precursor cell (APC) behavior to either proliferate or differentiate in response to systemic cues, such as elevated caloric intake. Further, our studies identified the non-muscle myosin protein MYH9 as a key target of this pathway to modulate adipogenesis in vivo. These findings enable strategies toward developing novel therapeutics for obesity and related metabolic disorders.

Indexed as

AdipogenesisGlucocorticoidsAdipocytesDiet, High-FatHumansObesityGlucocorticoids

Identifiers

PMID37944652
PMCPMC11005958
OpenAlexW4388451526

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.