ArticleJournal of affective disorders2024
Sleep, brain systems, and persistent stress in early adolescents during COVID-19: Insights from the ABCD study.
Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Contributions of genetic liability and the COVID-19 pandemic to rising psychopathology among youth in the United States.Translational psychiatry · 2026Article
- Identification of depressive symptoms in adolescents using machine learning combining childhood and adolescence features.BMC public health · 2025Article
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe first year of the COVID-19 pandemic constituted a major life stress event for many adolescents, associated with disrupted school, behaviors, social networks, and health concerns. However, pandemic-related stress was not equivalent for everyone and could have been influenced by pre-pandemic factors including brain structure and sleep, which both undergo substantial development during adolescence. Here, we analyzed clusters of perceived stress levels across the pandemic and determined developmentally relevant pre-pandemic risk factors in brain structure and sleep of persistently high stress during the first year of the COVID-19 pandemic.
methodsWe investigated longitudinal changes in perceived stress at six timepoints across the first year of the pandemic (May 2020-March 2021) in 5559 adolescents (50 % female; age range: 11-14 years) in the United States (U.S.) participating in the Adolescent Brain Cognitive Development (ABCD) study. In 3141 of these adolescents, we fitted machine learning models to identify the most important pre-pandemic predictors from structural MRI brain measures and self-reported sleep data that were associated with persistently high stress across the first year of the pandemic.
resultsPatterns of perceived stress levels varied across the pandemic, with 5 % reporting persistently high stress. Our classifiers accurately detected persistently high stress (AUC > 0.7). Pre-pandemic brain structure, specifically cortical volume in temporal regions, and cortical thickness in multiple parietal and occipital regions, predicted persistent stress. Pre-pandemic sleep difficulties and short sleep duration were also strong predictors of persistent stress, along with more advanced pubertal stage.
conclusionsAdolescents showed variable stress responses during the first year of the COVID-19 pandemic, and some reported persistently high stress across the whole first year. Vulnerability to persistent stress was evident in several brain structural and self-reported sleep measures, collected before the pandemic, suggesting the relevance of other pre-existing individual factors beyond pandemic-related factors, for persistently high stress responses.
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Registered trials
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