Evidence map›Paper›PMID 37945647›Full record

ArticleScientific reports2023

Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells.

Isaac Jardin, Sandra Alvarado, Vanesa Jimenez-Velarde, Joel Nieto-Felipe, Jose J Lopez, Gines M Salido, Tarik Smani, Juan A Rosado

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  4. Article
  5. Article
  6. ORAI CaBiomolecules · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isaac JardinDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain. ijp@unex.es.
Sandra AlvaradoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Vanesa Jimenez-VelardeDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Joel Nieto-FelipeDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Jose J LopezDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Gines M SalidoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Tarik SmaniInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Juan A RosadoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain. jarosado@unex.es.
Universidad de Extremadura · ESUniversidad de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orai1 is the pore-forming subunit of the Ca

Indexed as

CalciumTriple Negative Breast NeoplasmsAnimalsCalcium ChannelsCalcium, DietaryCalcium SignalingHumansMammalsNeoplastic Stem CellsORAI1 ProteinStromal Interaction Molecule 1CalciumCalcium ChannelsCalcium, DietaryORAI1 ProteinStromal Interaction Molecule 1

Identifiers

PMID37945647
PMCPMC10636192
OpenAlexW4388529736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.