Evidence map›Paper›PMID 37950398›Full record

ArticleJournal of magnetic resonance imaging : JMRI2024

Dark Blood Contrast-Enhanced Brain MRI Using Echo-uT

Robert R Edelman, Nondas Leloudas, William J Ankenbrandt, Matthew T Walker, George C Bobustuc, Julian E Bailes, Aaron A Pruitt, Ioannis Koktzoglou

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Robert R EdelmanRadiology, NorthShore University HealthSystem, Evanston, Illinois, USA.ORCID 0000-0002-0013-8822
Nondas LeloudasRadiology, NorthShore University HealthSystem, Evanston, Illinois, USA.
William J AnkenbrandtRadiology, NorthShore University HealthSystem, Evanston, Illinois, USA.
Matthew T WalkerRadiology, NorthShore University HealthSystem, Evanston, Illinois, USA.
George C BobustucNeurology, NorthShore University HealthSystem, Evanston, Illinois, USA.
Julian E BailesNeurosurgery, NorthShore University HealthSystem, Evanston, Illinois, USA.
Aaron A PruittSiemens Medical Solutions, Chicago, Illinois, USA.
Ioannis KoktzoglouRadiology, NorthShore University HealthSystem, Evanston, Illinois, USA.ORCID 0000-0001-9335-2010

Funding

Improved Detection of Cerebral Metastases using a using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) MRI TechniqueR01CA263091 · NCI · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI Robert R. Edelman · 2022 to 2026
$2.3M
Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) TechniqueR21CA273280 · NCI · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI EDELMAN, ROBERT R. · 2022 to 2023
$410k
NCI NIH HHS R01 CA263091NCI NIH HHS R21 CA273280NIH HHS 1R01CA263091NIH HHS 1R21CA273280
6 · The paper itself

Abstract

backgroundThe widely used magnetization-prepared rapid gradient-echo (MPRAGE) sequence makes enhancing lesions and blood vessels appear bright after gadolinium administration. However, dark blood imaging using T1-weighted Sampling Perfection with Application optimized Contrast using different flip angle Evolution (T1 SPACE) can be advantageous since it improves the conspicuity of small metastases and leptomeningeal disease. As a potential alternative to T1 SPACE, we evaluated a new dark blood sequence called echo-uT PURPOSE: We compared the performance of echo-uT STUDY TYPE: Retrospective, IRB approved. SUBJECTS/PHANTOM: Phantom to assess flow properties of echo-uT FIELD STRENGTH/SEQUENCES: 3 Tesla/MPRAGE, T1 SPACE, Dixon fid-uT ASSESSMENT: Flow phantom signal vs. velocity as a function of flip angle and sequence. Qualitative image assessment on 4-point scale. Quantitative evaluation of tumor-to-brain contrast, apparent contrast-to-noise ratio (aCNR), and vessel-to-brain aCNR. STATISTICAL TESTS: Friedman and Mann-Whitney U tests. A P value <0.05 was considered statistically significant.

resultsIn the phantom, echo-uT DATA

conclusionVolumetric dark blood contrast-enhanced brain MRI is feasible using echo-uT EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 1.

Indexed as

BrainBrain NeoplasmsContrast MediaMagnetic Resonance ImagingPhantoms, ImagingAdultAgedAged, 80 and overFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMaleMiddle AgedReproducibility of ResultsContrast Mediabrain tumorcontrast enhancementdark blood MRIfast imaging with steady‐state free precessionunbalanced T1 relaxation‐enhanced steady‐state

Identifiers

PMID37950398
PMCPMC11087375

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.