Evidence map›Paper›PMID 37953279›Full record

ArticleNucleic acids research2024

DrugBank 6.0: the DrugBank Knowledgebase for 2024.

Craig Knox, Mike Wilson, Christen M Klinger, Mark Franklin, Eponine Oler, Alex Wilson, Allison Pon, Jordan Cox, Na Eun Lucy Chin, Seth A Strawbridge and 32 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 886 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
886citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

886 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Gut microbes · 2026
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  14. Genome-scale perturbation signatures from primary human CD4bioRxiv : the preprint server for biology · 2026
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  15. Antibiotics (Basel, Switzerland) · 2026
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  16. Explainable Plasma Proteomics-Based Machine Learning for Osteoporosis Diagnosis, Prognosis, and Protein Biomarker Discovery in the UK Biobank.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

826 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Craig KnoxOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Mike WilsonOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Christen M KlingerOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Mark FranklinOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Eponine OlerDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Alex WilsonOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Allison PonOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Jordan CoxOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Na Eun Lucy ChinOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Seth A StrawbridgeOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Marysol Garcia-PatinoOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Ray KrugerDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Aadhavya SivakumaranDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Selena SanfordDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Rahil DoshiDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Nitya KhetarpalDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Omolola FatokunDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Daphnee DoucetDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Ashley ZubkowskiDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Dorsa Yahya RayatDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Hayley JacksonDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Karxena HarfordDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Afia AnjumDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Mahi ZakirDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Fei WangDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Siyang TianDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Brian LeeDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Jaanus LiigandDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Harrison PetersDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Ruo Qi Rachel WangOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Tue NguyenOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Denise SoOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Matthew SharpOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Rodolfo da SilvaOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Cyrella GabrielOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Joshua ScantleburyOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Marissa JasinskiOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
David AckermanOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Timothy JewisonOMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
Tanvir SajedDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Vasuk GautamDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
David S WishartDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.ORCID 0000-0002-3207-2434

Funding

CIHR
6 · The paper itself

Abstract

First released in 2006, DrugBank (https://go.drugbank.com) has grown to become the 'gold standard' knowledge resource for drug, drug-target and related pharmaceutical information. DrugBank is widely used across many diverse biomedical research and clinical applications, and averages more than 30 million views/year. Since its last update in 2018, we have been actively enhancing the quantity and quality of the drug data in this knowledgebase. In this latest release (DrugBank 6.0), the number of FDA approved drugs has grown from 2646 to 4563 (a 72% increase), the number of investigational drugs has grown from 3394 to 6231 (a 38% increase), the number of drug-drug interactions increased from 365 984 to 1 413 413 (a 300% increase), and the number of drug-food interactions expanded from 1195 to 2475 (a 200% increase). In addition to this notable expansion in database size, we have added thousands of new, colorful, richly annotated pathways depicting drug mechanisms and drug metabolism. Likewise, existing datasets have been significantly improved and expanded, by adding more information on drug indications, drug-drug interactions, drug-food interactions and many other relevant data types for 11 891 drugs. We have also added experimental and predicted MS/MS spectra, 1D/2D-NMR spectra, CCS (collision cross section), RT (retention time) and RI (retention index) data for 9464 of DrugBank's 11 710 small molecule drugs. These and other improvements should make DrugBank 6.0 even more useful to a much wider research audience ranging from medicinal chemists to metabolomics specialists to pharmacologists.

Indexed as

Knowledge BasesMetabolomicsTandem Mass SpectrometryDatabases, FactualFood-Drug Interactions

Identifiers

PMID37953279
PMCPMC10767804

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.